发明授权
- 专利标题: Delivery of nucleotides into organisms by electroporation
- 专利标题(中): 通过电穿孔将核苷酸递送到生物体中
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申请号: US471642申请日: 1995-06-06
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公开(公告)号: US5749847A公开(公告)日: 1998-05-12
- 发明人: Thomas E. Zewert , Uwe Pliquett , Robert S. Langer , James C. Weaver
- 申请人: Thomas E. Zewert , Uwe Pliquett , Robert S. Langer , James C. Weaver
- 申请人地址: MA Cambridge
- 专利权人: Massachusetts Institute of Technology
- 当前专利权人: Massachusetts Institute of Technology
- 当前专利权人地址: MA Cambridge
- 主分类号: A61B5/00
- IPC分类号: A61B5/00 ; A61K38/38 ; A61K38/48 ; A61K41/00 ; A61K48/00 ; A61N1/32 ; C07K14/82 ; C12N15/87 ; A61M31/00
摘要:
A method for delivering a nucleotide into an organism includes applying a composition which includes a nucleotide component to epidermis of the organism. The epidermis is electroporated, whereby at least a portion of the composition enters or passes across the epidermis, thereby delivering the nucleotide into the organism. An example of a suitable nucleotide which can be delivered by the method of the invention includes antisense oligodeoxynucleotides for treatment of melanomas.
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