发明授权
- 专利标题: Acylated oligopeptides for transfecting cells
- 专利标题(中): 用于转染细胞的酰化寡肽
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申请号: US752129申请日: 1996-11-20
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公开(公告)号: US5759827A公开(公告)日: 1998-06-02
- 发明人: Jean-Yves Legendre , Andreas Supersaxo , Arnold Trzeciak
- 申请人: Jean-Yves Legendre , Andreas Supersaxo , Arnold Trzeciak
- 申请人地址: NJ Nutley
- 专利权人: Hoffmann-La Roche Inc.
- 当前专利权人: Hoffmann-La Roche Inc.
- 当前专利权人地址: NJ Nutley
- 优先权: EPX95118338 19951122
- 主分类号: C12N15/09
- IPC分类号: C12N15/09 ; C07K5/068 ; C07K9/00 ; C12N15/87 ; C12N15/00
摘要:
Compounds of the formula R.sup.1 --NH--A I wherein R.sup.1 is an acyl moiety of a C.sub.12-40 aliphatic carboxylic acid, A is the residue of a oligopeptide devoid of one amino group, and --NH--A contains at least one positively charged amino acid, or derivatives thereof can be used for transferring anionic macromolecules into cells.
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