发明授权
- 专利标题: Biologically active peptides from funcional domains of bactericidal/permeability-increasing protein and uses thereof
- 专利标题(中): 来自杀菌/渗透性增加蛋白质的功能域的生物活性肽及其用途
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申请号: US473344申请日: 1995-06-07
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公开(公告)号: US5763567A公开(公告)日: 1998-06-09
- 发明人: Roger G. Little
- 申请人: Roger G. Little
- 申请人地址: CA Berkeley
- 专利权人: Xoma Corporation
- 当前专利权人: Xoma Corporation
- 当前专利权人地址: CA Berkeley
- 主分类号: A61K38/00
- IPC分类号: A61K38/00 ; A01N37/18 ; A61K9/12 ; A61K38/17 ; A61P1/00 ; A61P1/04 ; A61P3/10 ; A61P7/04 ; A61P9/00 ; A61P9/10 ; A61P9/14 ; A61P13/02 ; A61P15/00 ; A61P15/18 ; A61P17/02 ; A61P19/00 ; A61P19/02 ; A61P27/02 ; A61P27/06 ; A61P29/00 ; A61P31/04 ; A61P31/10 ; A61P35/00 ; A61P35/04 ; A61P37/06 ; A61P43/00 ; C07K7/06 ; C07K7/08 ; C07K14/47 ; C12P21/06 ; C07K7/00 ; C07K7/04
摘要:
The present invention provides peptides having an amino acid sequence that is the amino acid sequence of a human bactericidal/permeability-increasing protein (BPI) functional domain or a subsequence thereof, and variants of the sequence or subsequence thereof, having at least one of the BPI biological activities, such as heparin binding, heparin neutralization, LPS binding, LPS neutralization or bactericidal activity. The invention provides peptides and pharmaceutical compositions of such peptides for a variety of therapeutic uses.
公开/授权文献
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