- 专利标题： Automated allyl deprotection in solid-phase synthesis
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申请号： US803557申请日： 1997-02-20
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公开(公告)号： US5777077A公开(公告)日： 1998-07-07
- 发明人: Fernando Albericio , Steven A. Kates
- 申请人： Fernando Albericio , Steven A. Kates
- 申请人地址： MA Framingham
- 专利权人： PerSeptive Biosystems, Inc.
- 当前专利权人： PerSeptive Biosystems, Inc.
- 当前专利权人地址： MA Framingham
- 主分类号： B01J19/00
- IPC分类号： B01J19/00 ; B01J23/44 ; B01J31/24 ; B01J31/28 ; C07B61/00 ; C07K1/06 ; C07K1/113 ; C07K1/12 ; C40B40/10 ; C40B60/14
摘要：
A method for removing an allyl protecting group from an allyl-protected derivative of a biologically relevant amino acid is disclosed. One relevant aspect of the method is the use of soluble organometallic catalyst, such as an organopalladium catalyst. Preferably, soluble tetrakistriphenylphosphine palladium (0) is used. The allyl deprotection method now disclosed is suitable for use on an instrument for automated peptide synthesis. Methods of preparing the soluble organometallic catalyst are also disclosed, as are soluble catalyst compositions.
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