发明授权
- 专利标题: Alkylenediamine derivative anti-ulcer drug and antibacterial drug
- 专利标题(中): 烷二胺衍生物抗溃疡药和抗菌药
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申请号: US842891申请日: 1997-04-17
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公开(公告)号: US5814634A公开(公告)日: 1998-09-29
- 发明人: Chikao Nishino , Fumitaka Sato , Tomohiro Uetake , Hirotada Fukunishi , Nao Kojima
- 申请人: Chikao Nishino , Fumitaka Sato , Tomohiro Uetake , Hirotada Fukunishi , Nao Kojima
- 申请人地址: JPX Tokyo
- 专利权人: Shiseido Co. Ltd.
- 当前专利权人: Shiseido Co. Ltd.
- 当前专利权人地址: JPX Tokyo
- 优先权: JPX8-122195 19960418; JPX8-278871 19960930; JPX9-012056 19970106
- 主分类号: C07D295/12
- IPC分类号: C07D295/12 ; A61K31/445 ; A61K31/495 ; A61K31/505 ; A61K31/535 ; A61K31/5375 ; A61P1/04 ; A61P31/04 ; C07D211/14 ; C07D239/42 ; C07D277/20 ; C07D277/38 ; C07D277/82 ; C07D295/13 ; C07D317/58 ; C07D211/32 ; C07D265/30
摘要:
The invention provides a compound which has anti-ulcer effect and antibacterial activity against Helicobacter pyroli. This compound is an alkylenediamine derivative or salt which has a general formula of (1): ##STR1## wherein each of R.sub.4, R.sub.5, and R.sub.6 is hydrogen or lower alkyl; n represents an integer of 1 to 6; Y is --CH.sub.2 --, --O--, or --N(R.sub.7)--, wherein R.sub.7 is lower alkyl, aryl, carbamoyl lower alkyl, aralkyl, or a heterocyclic group having 5 to 9 carbon numbers; and, W is a group expressed by formulas 2 or 3: ##STR2## wherein (1) in formula 2: each of R.sub.1 and R.sub.2 is hydrogen, lower alkoxy, alkenyloxy, or a halogen atom; each of R.sub.3 and R.sub.3 is methyl, prenyl, or geranyl; when one of R.sub.3 and R.sub.3 is prenyl or geranyl, the other must be a methyl group; and X is oxygen or sulfur; and (2) in formula 3, R.sub.10 is a lower alkyl, and R.sub.11 is a halogen atom.
公开/授权文献
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