发明授权
- 专利标题: Human netrin-1
- 专利标题(中): 人类netrin-1
-
申请号: US635137申请日: 1996-04-19
-
公开(公告)号: US5824775A公开(公告)日: 1998-10-20
- 发明人: Candace Swimmer , Anne Shyjan , David Leonardo , Yuan Zhang , Timothy Kennedy , Tito Serafini , Marc Tessier-Lavigne
- 申请人: Candace Swimmer , Anne Shyjan , David Leonardo , Yuan Zhang , Timothy Kennedy , Tito Serafini , Marc Tessier-Lavigne
- 申请人地址: CA Oakland
- 专利权人: The Regents of the University of California
- 当前专利权人: The Regents of the University of California
- 当前专利权人地址: CA Oakland
- 主分类号: C12N15/09
- IPC分类号: C12N15/09 ; A61K31/00 ; A61K38/00 ; A61K45/00 ; A61P25/00 ; C07K14/47 ; C07K14/475 ; C12N15/18 ; C12Q1/68 ; G01N33/15 ; G01N33/50 ; G01N33/566 ; C07K1/00 ; C07K14/00 ; C07K17/00
摘要:
Specific netrin proteins, nucleic acids which encode netrin proteins and hybridization reagents, probes and primers capable of hybridizing with netrin genes and methods for screening chemical libraries for lead compounds for pharmacological agents useful in the diagnosis or treatment of disease associated undesirable cell growth are provided. An exemplary screen involves forming a mixture comprising a recombinant netrin protein, a natural intracellular netrin protein binding target, and a candidate pharmacological agent; incubating the mixture under conditions whereby, but for the presence of said candidate pharmacological agent, said netrin protein selectively binds said binding target; and detecting the presence or absence of specific binding of said netrin protein to said binding target.
公开/授权文献
- US5333108A Drive slip control system 公开/授权日:1994-07-26