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    Polynucleotide encoding human netrin-1
    1.
    发明授权
    Polynucleotide encoding human netrin-1 有权
    编码人netrin-1的多核苷酸

    公开(公告)号：US06218526B1

    公开(公告)日：2001-04-17

    申请号：US09136981

    申请日：1998-08-20

    申请人： Candace Swimmer ,  Anne Shyjan ,  David Leonardo ,  Yuan Zhang ,  Timothy Kennedy ,  Tito Serafini ,  Marc Tessier-Lavigne

    发明人： Candace Swimmer ,  Anne Shyjan ,  David Leonardo ,  Yuan Zhang ,  Timothy Kennedy ,  Tito Serafini ,  Marc Tessier-Lavigne

    IPC分类号： C12N1518

    CPC分类号： C07K14/475 ,  A61K38/00

    摘要： Specific netrin proteins, nucleic acids which encode netrin proteins and hybridization reagents, probes and primers capable of hybridizing with netrin genes and methods for screening chemical libraries for lead compounds for pharmacological agents useful in the diagnosis or treatment of disease associated undesirable cell growth are provided. An exemplary screen involves forming a mixture comprising a recombinant netrin protein, a natural intracellular netrin protein binding target, and a candidate pharmacological agent; incubating the mixture under conditions whereby, but for the presence of said candidate pharmacological agent, said netrin protein selectively binds said binding target; and detecting the presence or absence of specific binding of said netrin protein to said binding target.

    摘要翻译： 提供了特异性netrin蛋白质，编码netrin蛋白质的核酸和杂交试剂，能够与netrin基因杂交的探针和引物以及用于筛选用于诊断或治疗疾病相关的不希望的细胞生长的药物的铅化合物的化学文库的方法。 示例性屏幕包括形成包含重组netrin蛋白质，天然细胞内netrin蛋白结合靶标和候选药理学试剂的混合物; 在这样的条件下孵育混合物，但是对于所述候选药理学试剂的存在，所述网蛋白选择性结合所述结合靶; 并检测所述网蛋白与所述结合靶的特异性结合的存在或不存在。

    Human netrin-1
    2.
    发明授权
    Human netrin-1 失效
    人类netrin-1

    公开(公告)号：US5824775A

    公开(公告)日：1998-10-20

    申请号：US635137

    申请日：1996-04-19

    申请人： Candace Swimmer ,  Anne Shyjan ,  David Leonardo ,  Yuan Zhang ,  Timothy Kennedy ,  Tito Serafini ,  Marc Tessier-Lavigne

    发明人： Candace Swimmer ,  Anne Shyjan ,  David Leonardo ,  Yuan Zhang ,  Timothy Kennedy ,  Tito Serafini ,  Marc Tessier-Lavigne

    IPC分类号： C12N15/09 ,  A61K31/00 ,  A61K38/00 ,  A61K45/00 ,  A61P25/00 ,  C07K14/47 ,  C07K14/475 ,  C12N15/18 ,  C12Q1/68 ,  G01N33/15 ,  G01N33/50 ,  G01N33/566 ,  C07K1/00 ,  C07K14/00 ,  C07K17/00

    CPC分类号： C07K14/475 ,  A61K38/00

    摘要： Specific netrin proteins, nucleic acids which encode netrin proteins and hybridization reagents, probes and primers capable of hybridizing with netrin genes and methods for screening chemical libraries for lead compounds for pharmacological agents useful in the diagnosis or treatment of disease associated undesirable cell growth are provided. An exemplary screen involves forming a mixture comprising a recombinant netrin protein, a natural intracellular netrin protein binding target, and a candidate pharmacological agent; incubating the mixture under conditions whereby, but for the presence of said candidate pharmacological agent, said netrin protein selectively binds said binding target; and detecting the presence or absence of specific binding of said netrin protein to said binding target.

    摘要翻译： 提供了特异性netrin蛋白质，编码netrin蛋白质的核酸和杂交试剂，能够与netrin基因杂交的探针和引物以及用于筛选用于诊断或治疗疾病相关的不希望的细胞生长的药物的铅化合物的化学文库的方法。 示例性屏幕包括形成包含重组netrin蛋白质，天然细胞内netrin蛋白结合靶标和候选药理学试剂的混合物; 在这样的条件下孵育混合物，但是对于所述候选药理学试剂的存在，所述网蛋白选择性结合所述结合靶; 并检测所述网蛋白与所述结合靶的特异性结合的存在或不存在。