发明授权
US5830860A Peptides with bactericidal activity and endotoxin neutralizing activity
for gram negative bacteria and methods for their use
失效
对于革兰氏阴性细菌具有杀菌活性和内毒素中和活性的肽及其使用方法
- 专利标题： Peptides with bactericidal activity and endotoxin neutralizing activity for gram negative bacteria and methods for their use
- 专利标题（中）： 对于革兰氏阴性细菌具有杀菌活性和内毒素中和活性的肽及其使用方法
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申请号： US653632申请日： 1996-05-24
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公开(公告)号： US5830860A公开(公告)日： 1998-11-03
- 发明人: Beulah H. Gray , Judith R. Haseman , Kevin H. Mayo
- 申请人： Beulah H. Gray , Judith R. Haseman , Kevin H. Mayo
- 申请人地址： MN Minneapolis
- 专利权人： Regents of the University of Minnesota
- 当前专利权人： Regents of the University of Minnesota
- 当前专利权人地址： MN Minneapolis
- 主分类号： A61K38/00
- IPC分类号： A61K38/00 ; A61L27/34 ; C07K14/00 ; C07K14/47 ; C07K14/52 ; C07K14/54 ; C07K14/655 ; A61K38/08 ; A61K38/10 ; A61K38/17
摘要：
The invention provides biologically active peptides derived from or corresponding to regions of a bactericidal permeability increasing factor (B/PI). The peptides are preferably about 10 to 100 amino acids long and have bactericidal and/or endotoxin neutralizing activity. The peptides can be prepared by automated protein synthesis or by recombinant DNA methods. The peptides are useful in methods to treat and prevent bacterial infection in the body and on surfaces. The peptides are also useful to treat endotoxin shock and have endotoxin neutralizing activity.