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公开(公告)号：US08716343B2
公开(公告)日：2014-05-06
申请号：US13454525
申请日：2012-04-24
申请人： Kevin H. Mayo , Thomas R. Hoye , Xuemei Chen
发明人： Kevin H. Mayo , Thomas R. Hoye , Xuemei Chen
IPC分类号： A61K31/195 , A61K31/015
CPC分类号： C07C235/20 , A61K31/015 , A61K31/09 , A61K31/135 , A61K31/155 , A61K31/216 , A61K31/4192 , C07C217/18 , C07C235/34 , C07C279/08 , C07D249/08
摘要： A class of topomimetic calixarene-based peptide mimetics is described. Calixarene-based peptide mimetics have various biological activities such as, for example, bactericidal activity, antiangiogenic activity, and/or antitumor activity. Methods of use and methods of designing calixarene-based peptide mimetics are described.
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2.发明授权Calixarene-based peptide conformation mimetics, methods of use, and methods of making 有权基于Calixarene的肽构象模拟物，使用方法和制备方法公开(公告)号：US08207228B2
公开(公告)日：2012-06-26
申请号：US11664641
申请日：2005-10-04
申请人： Kevin H. Mayo , Thomas R. Hoye , Xuemei Cheri
发明人： Kevin H. Mayo , Thomas R. Hoye , Xuemei Cheri
IPC分类号： A61K31/195 , A61K31/015
CPC分类号： C07C235/20 , A61K31/015 , A61K31/09 , A61K31/135 , A61K31/155 , A61K31/216 , A61K31/4192 , C07C217/18 , C07C235/34 , C07C279/08 , C07D249/08
摘要： A class of topomimetic calixarene-based peptide mimetics is described. Calixarene-based peptide mimetics have various biological activities such as, for example, bactericidal activity, antiangiogenic activity, and/or antitumor activity. Methods of use and methods of designing calixarene-based peptide mimetics are described.
摘要翻译： 描述了一类基于开模的杯芳烃类模拟物。 基于杯芳烃的肽模拟物具有各种生物学活性，例如杀菌活性，抗血管生成活性和/或抗肿瘤活性。 描述了使用方法和设计基于杯芳烃的肽模拟物的方法。
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3.发明申请CALIXARENE-BASED PEPTIDE CONFORMATION MIMETICS, METHODS OF USE, AND METHODS OF MAKING 有权基于钙调蛋白的肽配合物质，使用方法和制备方法公开(公告)号：US20120309801A1
公开(公告)日：2012-12-06
申请号：US13454525
申请日：2012-04-24
申请人： Kevin H. Mayo , Thomas R. Hoye , Xuemei Chen
发明人： Kevin H. Mayo , Thomas R. Hoye , Xuemei Chen
IPC分类号： A61K31/165 , C07D403/14 , A61K31/4196 , C12N5/071 , A61K31/137 , C07C279/12 , A61K31/155 , A61P31/04 , C07C237/20 , C07C211/31
CPC分类号： C07C235/20 , A61K31/015 , A61K31/09 , A61K31/135 , A61K31/155 , A61K31/216 , A61K31/4192 , C07C217/18 , C07C235/34 , C07C279/08 , C07D249/08
摘要： A class of topomimetic calixarene-based peptide mimetics is described. Calixarene-based peptide mimetics have various biological activities such as, for example, bactericidal activity, antiangiogenic activity, and/or antitumor activity. Methods of use and methods of designing calixarene-based peptide mimetics are described.
摘要翻译： 描述了一类基于开模的杯芳烃类模拟物。 基于杯芳烃的肽模拟物具有各种生物学活性，例如杀菌活性，抗血管生成活性和/或抗肿瘤活性。 描述了使用方法和设计基于杯芳烃的肽模拟物的方法。
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4.发明授权Peptides with bactericidal activity and endotoxin neutralizing activity for gram negative bacteria and methods for their use 失效对于革兰氏阴性细菌具有杀菌活性和内毒素中和活性的肽及其使用方法
公开(公告)号：US5830860A
公开(公告)日：1998-11-03
申请号：US653632
申请日：1996-05-24
申请人： Beulah H. Gray , Judith R. Haseman , Kevin H. Mayo
发明人： Beulah H. Gray , Judith R. Haseman , Kevin H. Mayo
IPC分类号： A61K38/00 , A61L27/34 , C07K14/00 , C07K14/47 , C07K14/52 , C07K14/54 , C07K14/655 , A61K38/08 , A61K38/10 , A61K38/17
CPC分类号： A61L27/34 , C07K14/001 , C07K14/4742 , C07K14/522 , C07K14/5421 , C07K14/655 , A61K38/00
摘要： The invention provides biologically active peptides derived from or corresponding to regions of a bactericidal permeability increasing factor (B/PI). The peptides are preferably about 10 to 100 amino acids long and have bactericidal and/or endotoxin neutralizing activity. The peptides can be prepared by automated protein synthesis or by recombinant DNA methods. The peptides are useful in methods to treat and prevent bacterial infection in the body and on surfaces. The peptides are also useful to treat endotoxin shock and have endotoxin neutralizing activity.
摘要翻译： 本发明提供了衍生自或对应于杀菌剂渗透性增加因子（B / PI）的区域的生物活性肽。 肽优选为约10至100个氨基酸长并具有杀菌和/或内毒素中和活性。 肽可以通过自动蛋白质合成或重组DNA方法制备。 该肽可用于治疗和预防身体和表面的细菌感染的方法。 肽也可用于治疗内毒素休克并具有内毒素中和活性。
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5.发明申请Calixarene-Based Peptide Conformation Mimetics, Methods of Use, and Methods of Making 有权基于Calixarene的肽构象模拟物，使用方法和制备方法公开(公告)号：US20080300164A1
公开(公告)日：2008-12-04
申请号：US11664641
申请日：2005-10-04
申请人： Kevin H. Mayo , Thomas R. Hoye , Xuemei Chen
发明人： Kevin H. Mayo , Thomas R. Hoye , Xuemei Chen
IPC分类号： A61K38/02 , A01N37/18 , A01N47/44 , A01N43/653 , A01N43/647 , A01N33/04 , C12N5/06 , A61K31/165 , A61K31/155 , A01P1/00 , A61K31/4196 , A61K31/4192 , A61K31/137
CPC分类号： C07C235/20 , A61K31/015 , A61K31/09 , A61K31/135 , A61K31/155 , A61K31/216 , A61K31/4192 , C07C217/18 , C07C235/34 , C07C279/08 , C07D249/08
摘要： A class of topomimetic calixarene-based peptide mimetics is described. Calixarene-based peptide mimetics have various biological activities such as, for example, bactericidal activity, antiangiogenic activity, and/or antitumor activity. Methods of use and methods of designing calixarene-based peptide mimetics are described.
摘要翻译： 描述了一类基于开模的杯芳烃类模拟物。 基于杯芳烃的肽模拟物具有各种生物学活性，例如杀菌活性，抗血管生成活性和/或抗肿瘤活性。 描述了使用方法和设计基于杯芳烃的肽模拟物的方法。
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公开(公告)号：US07144982B2
公开(公告)日：2006-12-05
申请号：US09766353
申请日：2001-01-19
申请人： Kevin H. Mayo
发明人： Kevin H. Mayo
CPC分类号： C07K14/4723 , A61K38/00 , A61L2/0088 , A61L2/18
摘要： Polypeptides and methods of use including treating bacterial infection and/or endotoxemia, decreasing the amount of TNF-α, inhibiting endothelial cell proliferation, inhibiting angiogenic-factor mediated inter-cellular adhesion molecule expression down-regulation, and inhibiting angiogenesis.
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公开(公告)号：US5955577A
公开(公告)日：1999-09-21
申请号：US671487
申请日：1996-06-27
申请人： Kevin H. Mayo
发明人： Kevin H. Mayo
CPC分类号： C07K14/001 , C07K14/4742 , C07K14/522 , C07K14/5421 , C07K14/655 , A61K38/00
摘要： A method for synthesizing a water-soluble .beta.-sheet forming peptide having at least about 35% amino acids having hydrophobic side chains, the method comprising linking amino acids having charged side chains and amino acids having noncharged polar side chains with amino acids having hydrophobic side chains, wherein the amino acids having charged side chains are provided in a ratio of at least about 2:1 amino acids having positively charged side chains to amino acids having negatively charged side chains; wherein the peptide is water soluble under physiological conditions and forms .beta.-sheet structures.
摘要翻译： 一种用于合成具有至少约35％具有疏水侧链的氨基酸的水溶性β-折叠形成肽的方法，所述方法包括将具有带电侧链的氨基酸和具有非电荷极性侧链的氨基酸与具有疏水侧的氨基酸 链，其中具有带电侧链的氨基酸以具有带正电荷的侧链的至少约2:1的氨基酸与具有带负电荷侧链的氨基酸的比例提供; 其中所述肽在生理条件下是水溶性的并形成β-折叠结构。
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公开(公告)号：US07056514B2
公开(公告)日：2006-06-06
申请号：US10371406
申请日：2003-02-20
CPC分类号： C07K7/08 , A61K38/00 , C07K5/101 , C07K14/001 , C07K14/4747
摘要： Partial peptide mimetics and methods of making and using, wherein the partial peptide mimetics have a first amino acid sequence comprising ANIKLSVQMKL (SEQ ID NO:8), a homolog thereof, or a segment of SEQ ID NO:8 or a homolog thereof, a second amino acid sequence comprising IIVKLND (SEQ ID NO:2), a homolog thereof, or a segment of SEQ ID NO:2 or a homolog thereof, and a β-turn inducing scaffold bonded between the first and second amino acid sequences.
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公开(公告)号：US07339023B2
公开(公告)日：2008-03-04
申请号：US11346504
申请日：2006-02-02
IPC分类号： C07K1/00
CPC分类号： C07K7/08 , A61K38/00 , C07K5/101 , C07K14/001 , C07K14/4747
摘要： Partial peptide mimetics and methods of making and using, wherein the partial peptide mimetics have a first amino acid sequence comprising ANIKLSVQMKL (SEQ ID NO:8), a homolog thereof, or a segment of SEQ ID NO:8 or a homolog thereof, a second amino acid sequence comprising IIVKLND (SEQ ID NO:2), a homolog thereof, or a segment of SEQ ID NO:2 or a homolog thereof, and a β-turn inducing scaffold bonded between the first and second amino acid sequences.
摘要翻译： 部分肽模拟物和制备和使用方法，其中部分肽模拟物具有包含ANIKLSVQMKL（SEQ ID NO：8），其同源物或SEQ ID NO：8的片段或其同源物的第一氨基酸序列， 包含IIVKLND（SEQ ID NO：2），其同源物或SEQ ID NO：2的片段或其同源物的第二氨基酸序列和键合在第一和第二氨基酸序列之间的β-转角诱导支架。
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