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1.发明授权Peptides with bactericidal activity and endotoxin neutralizing activity for gram negative bacteria and methods for their use 失效对于革兰氏阴性细菌具有杀菌活性和内毒素中和活性的肽及其使用方法
公开(公告)号：US5830860A
公开(公告)日：1998-11-03
申请号：US653632
申请日：1996-05-24
申请人： Beulah H. Gray , Judith R. Haseman , Kevin H. Mayo
发明人： Beulah H. Gray , Judith R. Haseman , Kevin H. Mayo
IPC分类号： A61K38/00 , A61L27/34 , C07K14/00 , C07K14/47 , C07K14/52 , C07K14/54 , C07K14/655 , A61K38/08 , A61K38/10 , A61K38/17
CPC分类号： A61L27/34 , C07K14/001 , C07K14/4742 , C07K14/522 , C07K14/5421 , C07K14/655 , A61K38/00
摘要： The invention provides biologically active peptides derived from or corresponding to regions of a bactericidal permeability increasing factor (B/PI). The peptides are preferably about 10 to 100 amino acids long and have bactericidal and/or endotoxin neutralizing activity. The peptides can be prepared by automated protein synthesis or by recombinant DNA methods. The peptides are useful in methods to treat and prevent bacterial infection in the body and on surfaces. The peptides are also useful to treat endotoxin shock and have endotoxin neutralizing activity.
摘要翻译： 本发明提供了衍生自或对应于杀菌剂渗透性增加因子（B / PI）的区域的生物活性肽。 肽优选为约10至100个氨基酸长并具有杀菌和/或内毒素中和活性。 肽可以通过自动蛋白质合成或重组DNA方法制备。 该肽可用于治疗和预防身体和表面的细菌感染的方法。 肽也可用于治疗内毒素休克并具有内毒素中和活性。
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公开(公告)号：US07030087B2
公开(公告)日：2006-04-18
申请号：US10300083
申请日：2002-11-20
CPC分类号： C07K14/655 , A61K38/00 , A61L27/34 , C07K14/001 , C07K14/4742 , C07K14/522 , C07K14/5421 , C07K2319/00 , C08L89/00
摘要： This invention relates to the chemical design and production of peptides, peptide structure and three dimensional conformation was assessed using NMR, circular dichroisin and pulsed field gradient NMR. In addition, this invention relates to peptides produced by these methods and to methods for using the peptides.
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公开(公告)号：US20080261880A1
公开(公告)日：2008-10-23
申请号：US12005896
申请日：2007-12-28
CPC分类号： C07K14/655 , A61K38/00 , A61L27/34 , C07K14/001 , C07K14/4742 , C07K14/522 , C07K14/5421 , C07K2319/00 , C08L89/00
摘要： This invention relates to the chemical design and production of peptides, peptide structure and three dimensional conformation was assessed using NMR, circular dichroisin and pulsed field gradient NMR. In addition, this invention relates to peptides produced by these methods and to methods for using the peptides.
摘要翻译： 本发明涉及肽的化学设计和生产，肽结构和三维构象使用NMR，环状二色菌素和脉冲场梯度NMR进行评估。 此外，本发明涉及通过这些方法产生的肽以及使用肽的方法。
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