- 专利标题： Oncoprotein protein kinase
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申请号： US711893申请日： 1996-09-12
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公开(公告)号： US5837244A公开(公告)日： 1998-11-17
- 发明人: Michael Karin , Masahiko Hibi , Anning Lin
- 申请人： Michael Karin , Masahiko Hibi , Anning Lin
- 申请人地址： CA Oakland
- 专利权人： The Regents of the University of California
- 当前专利权人： The Regents of the University of California
- 当前专利权人地址： CA Oakland
- 主分类号： G01N33/573
- IPC分类号： G01N33/573 ; A61K31/00 ; A61K38/00 ; A61K39/395 ; A61P5/40 ; A61P9/08 ; A61P9/10 ; A61P25/04 ; A61P29/00 ; A61P31/00 ; A61P31/12 ; A61P35/00 ; A61P35/02 ; A61P37/00 ; A61P37/02 ; A61P43/00 ; C07H21/04 ; C07K14/705 ; C07K14/82 ; C07K16/30 ; C07K16/32 ; C07K16/40 ; C12N5/10 ; C12N9/12 ; C12N15/02 ; C12N15/09 ; C12N15/54 ; C12P21/08 ; C12Q1/68 ; G01N33/574 ; G01N33/577 ; A61K31/90
摘要：
An isolated polypeptide (JNK) characterized by having a molecular weight of 46 kD as determined by reducing SDS-PAGE, having serine and threonine kinase activity, phosphorylating the c-Jun N-terminal activation domain and polynucleotide sequences and method of detection of JNK are provided herein. JNK phosphorylates c-Jun N-terminal activation domain which affects gene expression from AP-1 sites.
公开/授权文献
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