发明授权
US5861380A Serine protease inhibitors-keto and di-keto containing ring systems
失效
丝氨酸蛋白酶抑制剂 - 酮和含二酮的环系
- 专利标题： Serine protease inhibitors-keto and di-keto containing ring systems
- 专利标题（中）： 丝氨酸蛋白酶抑制剂 - 酮和含二酮的环系
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申请号： US760916申请日： 1996-12-06
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公开(公告)号： US5861380A公开(公告)日： 1999-01-19
- 发明人: Albert Gyorkos , Lyle W. Spruce
- 申请人： Albert Gyorkos , Lyle W. Spruce
- 申请人地址： CO Denver
- 专利权人： Cortech, Inc.
- 当前专利权人： Cortech, Inc.
- 当前专利权人地址： CO Denver
- 主分类号： A61K38/00
- IPC分类号： A61K38/00 ; A61P9/00 ; A61P11/00 ; A61P43/00 ; C07D249/08 ; C07D271/10 ; C07D413/12 ; C07D413/14 ; C07D417/12 ; C07K5/02 ; C07K5/06 ; C07K5/062 ; C07K5/065 ; C07K5/068 ; C07K5/072 ; C07K5/078 ; C07K5/08 ; C07K5/083 ; C07K5/12 ; A61K31/16 ; A61K38/05 ; C07D233/96
摘要：
The present invention relates to certain substituted oxadiazole, thiadiazole and triazole peptoids which are useful as inhibitors of human neutrophil elastase (HNE) for the treatment of HNE-mediated processes implicated in conditions such as adult respiratory distress syndrome, septic shock and multiple organ failure. A series of studies also have indicated the involvement HNE in myocardial ischemia-reperfusion injury, emphysema. HNE-mediated processes are implicated in other conditions such as arthritis, periodontal disease, glomerulonephritis, dermatitis, psoriasis, cystic fibrosis, chronic bronchitis, atherosclerosis, Alzheimer's disease, organ transplantation, corneal ulcers, and invasion behavior of malignant tumors.
公开/授权文献
- US5235766A Product indentification tag for flat bar hook 公开/授权日：1993-08-17
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