发明授权
US5863739A Assay and kit for the detection of .alpha. platelet derived growth
factor receptor
失效
用于检测α血小板衍生生长因子受体的测定和试剂盒
- 专利标题： Assay and kit for the detection of .alpha. platelet derived growth factor receptor
- 专利标题（中）： 用于检测α血小板衍生生长因子受体的测定和试剂盒
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申请号： US460069申请日： 1995-06-02
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公开(公告)号： US5863739A公开(公告)日： 1999-01-26
- 发明人: William J. LaRochelle , Jacalyn Pierce , Roy A. Jensen , Stuart A. Aaronson
- 申请人： William J. LaRochelle , Jacalyn Pierce , Roy A. Jensen , Stuart A. Aaronson
- 申请人地址： DC Washington
- 专利权人： The United States of America as represented by the Department of Health and Human Services
- 当前专利权人： The United States of America as represented by the Department of Health and Human Services
- 当前专利权人地址： DC Washington
- 主分类号： G01N33/50
- IPC分类号： G01N33/50 ; A61K38/00 ; A61K39/395 ; A61K51/00 ; A61K51/10 ; C07K14/71 ; C07K16/22 ; C07K16/28 ; C07K16/46 ; C12N5/20 ; C12N15/02 ; C12N15/09 ; C12P21/08 ; C12R1/91 ; G01N33/53 ; G01N33/531 ; G01N33/566 ; G01N33/577 ; G01N33/74
摘要：
Potent neutralizing monoclonal antibodies to the human .alpha. PDGF receptor (.alpha. PDGFR) and fragments thereof are described. These monoclonal antibodies specifically bind to an epitope on .alpha. PDGFR, inhibits PDGF binding with PDGF, antagonizes PDGF, and does not bind .beta. PDGFR receptor. A hybridoma cell line producing such a monoclonal antibody, methods of in vivo imaging of a pathological conditions and methods of inhibiting the growth of a neoplasia expressing .alpha. PDGFR, which use these monoclonal antibodies are also described. In vitro assays for detecting the presence of .alpha. PDGFR and for evaluating the binding affinity of a test compound are also described.
公开/授权文献
- US5151864A Method of generating cutting passes of complex curved surface 公开/授权日：1992-09-29
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