发明授权
- 专利标题: Medicines for cardiac insufficiency
- 专利标题(中): 心脏功能不全的药物
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申请号: US530252申请日: 1995-09-29
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公开(公告)号: US5919806A公开(公告)日: 1999-07-06
- 发明人: Kiyotomo Seto , Hiroo Matsumoto , Yoshimasa Kamikawaji , Kazuhiko Ohrai , Toru Yamashita , Yukinori Masuda
- 申请人: Kiyotomo Seto , Hiroo Matsumoto , Yoshimasa Kamikawaji , Kazuhiko Ohrai , Toru Yamashita , Yukinori Masuda
- 申请人地址: JPX Tokyo
- 专利权人: Nissan Chemical Industries, Ltd.
- 当前专利权人: Nissan Chemical Industries, Ltd.
- 当前专利权人地址: JPX Tokyo
- 优先权: JPX5-076860 19930402; JPX6-037303 19940308
- 主分类号: A61K31/41
- IPC分类号: A61K31/41 ; A61K31/4178 ; A61K31/4192 ; A61K31/422 ; A61K31/4245 ; A61K31/433 ; A61K31/454 ; A61K31/4725 ; A61K31/496 ; A61K31/506 ; A61K31/5355 ; A61K31/5377 ; A61P9/04 ; C07D491/04 ; C07D491/052 ; C07D498/04 ; C07D513/04 ; A61K31/37
摘要:
Disclosed are cardiotonic medicines containing, as the active ingredient, at least one of compounds of formula (I) and their pharmacologically acceptable salts when they form salts. ##STR1## wherein X.sup.1 and X.sup.2 do not exist or represents an oxygen atom; A represents OH or a C.sub.1 -C.sub.4 acyloxy group; B represents a hydrogen atom or may form a chemical bond along with A; X is an oxygen atom, nitrogen, sulfur, etc.; R.sup.1 and R.sup.2 each represents a hydrogen atom, a C.sub.1 -C.sub.4 alkyl group, etc.; R.sup.3 and R.sup.4 each represents a hydrogen atom, a C.sub.1 -C.sub.4 alkyl group, etc., or they may together form a 1,4-butylene or 1,5-pentylene group. The compounds have a strong activity of reinforcing the contraction of cardiac muscles and a strong activity of reducing the rate of heart beats. As they are not toxic, they are useful as cardiotonic medicines.
公开/授权文献
- USD322310S Ceiling fan 公开/授权日:1991-12-10
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