发明授权
- 专利标题： Cardiac diseases improving agents
- 专利标题（中）： 心脏疾病改善剂
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申请号： US991411申请日： 1997-12-16
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公开(公告)号： US5932575A公开(公告)日： 1999-08-03
- 发明人: Mikiro Yanaka , Fuyuhiko Nishijima , Mikio Sugano , Hiroshi Takahashi , Shigeru Suzuki , Hiroyuki Enari , Michihito Ise
- 申请人： Mikiro Yanaka , Fuyuhiko Nishijima , Mikio Sugano , Hiroshi Takahashi , Shigeru Suzuki , Hiroyuki Enari , Michihito Ise
- 申请人地址： JPX Tokyo
- 专利权人： Kureha Chemical Industry Co., Ltd.
- 当前专利权人： Kureha Chemical Industry Co., Ltd.
- 当前专利权人地址： JPX Tokyo
- 优先权： JPX9-020925 19970121
- 主分类号： C07D295/18
- IPC分类号： C07D295/18 ; A61K31/40 ; A61K31/44 ; A61K31/495 ; A61K31/535 ; A61K31/5375 ; A61P9/00 ; A61P9/08 ; A61P9/10 ; A61P9/12 ; C07D207/16 ; C07D207/24 ; C07D213/79 ; C07D257/04 ; C07D295/192 ; A61K31/445
摘要：
This invention relates to cardiac diseases improving agents substantially free from antagonistic action to type 1 receptor of angiotensin II which participates to hypotensive action. Particularly, this invention relates to cardiac diseases improving agents composed of effective ingredients of aromatic compounds or pharmacologically acceptable salts thereof shown by below mentioned general formula. ##STR1## (wherein, substituents thereof typically include, R.sup.1, R.sup.4, R.sup.13 representing hydrogen atom, an alkyl group, a haloalkyl group and so forth, R.sup.8 representing --CO--, --SO.sub.2 -- or single bond, R.sup.2 representing a 3-7 membered aliphatic cyclic amino group having at least one nitrogen atom, R.sup.7 representing --CO-- or --SO.sub.2 --, and R.sup.12 representing N-substituted valeramido group.)
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