发明授权
- 专利标题： Muscarinic antagonists
- 专利标题（中）： 毒蕈碱拮抗剂
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申请号： US883183申请日： 1997-06-26
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公开(公告)号： US5935958A公开(公告)日： 1999-08-10
- 发明人: Joseph A. Kozlowski , Derek B. Lowe , Wei K. Chang , Sundeep Dugar
- 申请人： Joseph A. Kozlowski , Derek B. Lowe , Wei K. Chang , Sundeep Dugar
- 申请人地址： NJ Kenilworth
- 专利权人： Schering Corporation
- 当前专利权人： Schering Corporation
- 当前专利权人地址： NJ Kenilworth
- 主分类号： C07D211/58
- IPC分类号： C07D211/58 ; C07D239/34 ; C07D295/096 ; C07D311/74 ; A61K31/495 ; A61K31/445 ; C07D401/12 ; C07D405/14
摘要：
Di-N-substituted piperazine or 1,4-di-substituted piperidine compounds in accordance with formula I (including all isomers, salts, esters, and solvates) ##STR1## wherein Q, n, R, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.21, R.sup.27, R.sup.28, X, and Z are as defined herein are muscarinic antagonists useful for treating cognitive disorders such as Alzheimer's disease. Pharmaceutical compositions and methods of preparation are also disclosed. Also disclosed are synergistic combinations with acetyl-cholinesterase inhibitors of compounds capable of enhancing acetylcholine release and having the above formula.
公开/授权文献
- US5343115A Efficient large area multi-channel flat fluorescent lamp 公开/授权日：1994-08-30
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