发明授权
US5952320A Macrocyclic inhibitors of matrix metalloproteinases and TNF.alpha.
secretion
失效
基质金属蛋白酶和TNFα分泌的大环抑制剂
- 专利标题： Macrocyclic inhibitors of matrix metalloproteinases and TNF.alpha. secretion
- 专利标题（中）： 基质金属蛋白酶和TNFα分泌的大环抑制剂
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申请号： US992668申请日： 1997-12-17
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公开(公告)号： US5952320A公开(公告)日： 1999-09-14
- 发明人: Steven K. Davidsen , Douglas H. Steinman , George S. Sheppard , Lianhong Xu , James H. Holms , Yan Guo , James B. Summers , Alan S. Florjancic , Michael R. Michaelides
- 申请人： Steven K. Davidsen , Douglas H. Steinman , George S. Sheppard , Lianhong Xu , James H. Holms , Yan Guo , James B. Summers , Alan S. Florjancic , Michael R. Michaelides
- 申请人地址： IL Abbott Park
- 专利权人： Abbott Laboratories
- 当前专利权人： Abbott Laboratories
- 当前专利权人地址： IL Abbott Park
- 主分类号： C07D245/06
- IPC分类号： C07D245/06 ; C07D267/00 ; C07D413/04 ; C07D413/06 ; C07D413/12 ; C07D417/12 ; C07D487/08 ; A61K31/33 ; C07D225/04 ; C07D267/22 ; C07D281/18
摘要：
Macrocyclic compounds of formula ##STR1## are potent inhibitors of matrix metalloproteinase and are useful in the treatment of diseases in which matrix metalloproteinase play a role. Also disclosed are matrix metalloproteinase inhibiting compositions and a method of inhibiting matrix metalloproteinase in a mammal.
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