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公开(公告)号：US09296758B2
公开(公告)日：2016-03-29
申请号：US13806048
申请日：2011-07-01
申请人： Kerim Babaoglu , Kyla Bjornson , Hongyan Guo , Randall L. Halcomb , John O. Link , Hongtao Liu , Michael L. Mitchell , Jianyu Sun , James Taylor , Randall W. Vivian , Lianhong Xu
发明人： Kerim Babaoglu , Kyla Bjornson , Hongyan Guo , Randall L. Halcomb , John O. Link , Hongtao Liu , Michael L. Mitchell , Jianyu Sun , James Taylor , Randall W. Vivian , Lianhong Xu
IPC分类号： C07D498/04 , C07D215/06 , C07D215/14 , C07D215/18 , C07D215/227 , C07D215/38 , C07D215/48 , C07D401/04 , C07D401/12 , C07D405/04 , C07D413/04 , C07D417/04 , C07D487/04 , C07D519/00 , C07D491/052 , C07D215/20
CPC分类号： C07D498/04 , C07D215/06 , C07D215/14 , C07D215/18 , C07D215/20 , C07D215/227 , C07D215/38 , C07D215/48 , C07D401/04 , C07D401/12 , C07D405/04 , C07D413/04 , C07D417/04 , C07D487/04 , C07D491/052 , C07D519/00
摘要： The invention provides compounds of formula (I): or a salt thereof as described herein. The invention also provides pharmaceutical compositions comprising a compound of formula (I), processes for preparing compounds of formula (I), intermediates useful for preparing compounds of formula I and therapeutic methods for treating the proliferation of the HIV virus, treating AIDS or delaying the onset of AIDS or ARC symptoms in a mammal using compounds of formula (I).
摘要翻译： 本发明提供了本文所述的式（I）化合物或其盐。 本发明还提供包含式（I）化合物的药物组合物，制备式（I）化合物的方法，用于制备式I化合物的中间体和治疗HIV病毒增殖的治疗方法，治疗AIDS或延迟 使用式（I）化合物在哺乳动物中发生AIDS或ARC症状。
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公开(公告)号：US08759379B2
公开(公告)日：2014-06-24
申请号：US12340419
申请日：2008-12-19
申请人： Manoj C. Desai , Hon C. Hui , Hongtao Liu , Lianhong Xu
发明人： Manoj C. Desai , Hon C. Hui , Hongtao Liu , Lianhong Xu
IPC分类号： A61K31/341 , A61K31/34 , A61K31/5377 , A61K31/427 , C07D417/12 , C07D417/14 , C07D493/04 , C07D307/20
CPC分类号： A61K31/427 , A61K31/34 , A61K31/341 , A61K31/5377 , C07D277/28 , C07D307/20 , C07D417/12 , C07D417/14 , C07D493/04
摘要： The present application provides for a compound of Formula I, or a pharmaceutically acceptable salt, solvate, and/or ester thereof, compositions containing such compounds, therapeutic methods that include the administration of such compounds, and therapeutic methods and include the administration of such compounds with at least one additional therapeutic agent.
摘要翻译： 本申请提供式I化合物或其药学上可接受的盐，溶剂合物和/或酯，含有这些化合物的组合物，包括施用这些化合物的治疗方法和治疗方法，包括给予这些化合物 与至少一种另外的治疗剂。
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公开(公告)号：US08334295B2
公开(公告)日：2012-12-18
申请号：US12215450
申请日：2008-06-26
申请人： Hongyan Guo , Choung U. Kim , Ill Y. Lee , Michael L. Mitchell , Gerry Rhodes , Jong C. Son , Lianhong Xu
发明人： Hongyan Guo , Choung U. Kim , Ill Y. Lee , Michael L. Mitchell , Gerry Rhodes , Jong C. Son , Lianhong Xu
IPC分类号： A61K31/505
CPC分类号： A61K31/513 , A61K31/496 , A61K31/536 , A61K31/551 , A61K31/66 , A61K31/7048 , A61K31/7072 , A61K31/708 , A61K39/39558 , A61K45/06 , C07D239/54 , C07D239/545 , C07D239/553 , C07D239/60 , C07D401/04 , C07D403/04
摘要： The invention is related to compounds of Formula (I): or a pharmaceutically acceptable salt, solvate, ester, and/or phosphonate thereof, compositions containing such compounds, and therapeutic methods that include the administration of such compounds.
摘要翻译： 本发明涉及式（I）化合物或其药学上可接受的盐，溶剂合物，酯和/或膦酸盐，含有这些化合物的组合物，以及包括施用这些化合物的治疗方法。
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公开(公告)号：US20120157404A1
公开(公告)日：2012-06-21
申请号：US13291977
申请日：2011-11-08
申请人： Hongyan Guo , Darryl Kato , Thorsten A. Kirschberg , Hongtao Liu , John O. Link , Michael L. Mitchell , Jay P. Parrish , Jianyu Sun , James Taylor , Elizabeth M. Bacon , Eda Canales , Aesop Cho , Choung U. Kim , Jeromy J. Cottell , Manoj C. Desai , Randall L. Halcomb , Michael Graupe , Evan S. Krygowski , Scott E. Lazerwith , Qi Liu , Richard L. Mackman , Hyung-Jung Pyun , Joseph H. Saugier , James D. Trenkle , Winston C. Tse , Randall W. Vivian , Scott D. Schroeder , William J. Watkins , Lianhong Xu
发明人： Hongyan Guo , Darryl Kato , Thorsten A. Kirschberg , Hongtao Liu , John O. Link , Michael L. Mitchell , Jay P. Parrish , Jianyu Sun , James Taylor , Elizabeth M. Bacon , Eda Canales , Aesop Cho , Choung U. Kim , Jeromy J. Cottell , Manoj C. Desai , Randall L. Halcomb , Michael Graupe , Evan S. Krygowski , Scott E. Lazerwith , Qi Liu , Richard L. Mackman , Hyung-Jung Pyun , Joseph H. Saugier , James D. Trenkle , Winston C. Tse , Randall W. Vivian , Scott D. Schroeder , William J. Watkins , Lianhong Xu
IPC分类号： A61K31/4184 , A61K31/501 , A61K31/439 , A61K31/7056 , A61K31/7068 , A61K31/496 , A61P31/14
CPC分类号： C07D403/14 , A61K31/4025 , A61K31/4178 , A61K31/4184 , A61K31/427 , A61K31/435 , A61K31/437 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/519 , A61K31/5377 , A61K31/5415 , A61K31/55 , A61K45/06 , A61P31/12 , C07D207/16 , C07D401/14 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/08 , C07D471/10 , C07D487/04 , C07D491/113 , C07D495/04 , C07F5/025
摘要： The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
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公开(公告)号：US08148374B2
公开(公告)日：2012-04-03
申请号：US12036124
申请日：2008-02-22
申请人： Manoj C. Desai , Hongtao Liu , Lianhong Xu
发明人： Manoj C. Desai , Hongtao Liu , Lianhong Xu
IPC分类号： A61K31/5355 , C07D413/14 , C07D417/14
CPC分类号： G01N33/94 , A61K9/0053 , A61K9/08 , A61K31/4178 , A61K31/426 , A61K31/427 , A61K31/496 , A61K31/5377 , A61K45/06 , C07B2200/05 , C07D277/28 , C07D277/30 , C07D417/14 , G01N33/58 , A61K2300/00
摘要： The present application provides for a compound of Formula IV, or a pharmaceutically acceptable salt, solvate, and/or ester thereof, compositions containing such compounds, therapeutic methods that include the administration of such compounds, and therapeutic methods and include the administration of such compounds with at least one additional therapeutic agent.
摘要翻译： 本申请提供式IV化合物或其药学上可接受的盐，溶剂合物和/或酯，含有这些化合物的组合物，包括施用这些化合物的治疗方法和治疗方法，包括给予这些化合物 与至少一种另外的治疗剂。
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公开(公告)号：US20090306112A1
公开(公告)日：2009-12-10
申请号：US12307674
申请日：2007-07-19
申请人： Carina E. Cannizzaro , James M. Chen , Manoj C. Desai , Michael L. Mitchell , Sundaramoorthi Swaminathan , Lianhong Xu , Zheng-Yu Yang
发明人： Carina E. Cannizzaro , James M. Chen , Manoj C. Desai , Michael L. Mitchell , Sundaramoorthi Swaminathan , Lianhong Xu , Zheng-Yu Yang
IPC分类号： A61K31/505 , C07D405/02 , A61K31/443 , C12N5/00 , C12N7/04 , C07D405/14 , C07D215/38 , A61K31/47 , C07D417/02 , A61K31/4439 , C07D213/02 , A61K31/44 , C07D239/02 , C07D249/08 , A61K31/4196 , C07D257/04 , A61K31/41 , C07D277/22 , A61K31/426
CPC分类号： C07D405/12 , C07D213/56 , C07D401/12 , C07D405/14 , C07D407/12 , C07D409/12 , C07D417/12 , C07D493/04 , C07F9/65583 , C07F9/65586 , C07F9/6561
摘要： The invention is related to compounds of Formula I or a pharmaceutically acceptable salt, solvate, ester, and/or phosphonate thereof, compositions containing such compounds, and therapeutic methods that include the administration of such compounds.
摘要翻译： 本发明涉及式I化合物或其药学上可接受的盐，溶剂化物，酯和/或膦酸酯，含有这些化合物的组合物，以及包括施用这些化合物的治疗方法。
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公开(公告)号：US20090175820A1
公开(公告)日：2009-07-09
申请号：US12340419
申请日：2008-12-19
申请人： Manoj C. Desai , Hon C. Hui , Hongtao Liu , Lianhong Xu
发明人： Manoj C. Desai , Hon C. Hui , Hongtao Liu , Lianhong Xu
IPC分类号： A61K38/21 , C07D415/00 , A61K31/5377 , A61K31/427
CPC分类号： A61K31/427 , A61K31/34 , A61K31/341 , A61K31/5377 , C07D277/28 , C07D307/20 , C07D417/12 , C07D417/14 , C07D493/04
摘要： The present application provides for a compound of Formula I, or a pharmaceutically acceptable salt, solvate, and/or ester thereof, compositions containing such compounds, therapeutic methods that include the administration of such compounds, and therapeutic methods and include the administration of such compounds with at least one additional therapeutic agent.
摘要翻译： 本申请提供式I化合物或其药学上可接受的盐，溶剂合物和/或酯，含有这些化合物的组合物，包括施用这些化合物的治疗方法和治疗方法，包括给予这些化合物 与至少一种另外的治疗剂。
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公开(公告)号：US20090105279A1
公开(公告)日：2009-04-23
申请号：US11880069
申请日：2007-07-19
申请人： Carina E. Cannizzaro , James M. Chen , Manoj C. Desai , Michael L. Mitchell , Sundaramoorthi Swaminathan , Lianhong Xu , Zheng-Yu Yang
发明人： Carina E. Cannizzaro , James M. Chen , Manoj C. Desai , Michael L. Mitchell , Sundaramoorthi Swaminathan , Lianhong Xu , Zheng-Yu Yang
IPC分类号： C07D401/00 , C07D211/00 , A61K31/4427 , C07D405/00 , C07D215/38 , C07D249/08 , A61K31/4196 , C07D277/30 , C07D493/04 , C07F9/547 , C12N7/06 , A61K31/34 , C07D257/04 , A61K31/41 , C07D239/02 , A61K31/4709 , C07D417/00 , C07D409/00
CPC分类号： C07D405/12 , C07D213/56 , C07D401/12 , C07D405/14 , C07D407/12 , C07D409/12 , C07D417/12 , C07D493/04 , C07F9/65583 , C07F9/65586 , C07F9/6561
摘要： The invention is related to compounds of Formula I: or a pharmaceutically acceptable salt, solvate, ester, and/or phosphonate thereof, compositions containing such compounds, and therapeutic methods that include the administration of such compounds.
摘要翻译： 本发明涉及式I化合物或其药学上可接受的盐，溶剂合物，酯和/或膦酸盐，含有这些化合物的组合物，以及包括施用这些化合物的治疗方法。
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公开(公告)号：US20080207620A1
公开(公告)日：2008-08-28
申请号：US12036124
申请日：2008-02-22
申请人： Manoj C. Desai , Allen Y. Hong , Hon C. Hui , Hongtao Liu , Randall W. Vivian , Lianhong Xu
发明人： Manoj C. Desai , Allen Y. Hong , Hon C. Hui , Hongtao Liu , Randall W. Vivian , Lianhong Xu
IPC分类号： A61K31/5375 , C07D277/22 , A61P31/00 , C07D247/00 , A61K31/44 , A61K31/497 , C07D417/02 , A61K31/426
CPC分类号： G01N33/94 , A61K9/0053 , A61K9/08 , A61K31/4178 , A61K31/426 , A61K31/427 , A61K31/496 , A61K31/5377 , A61K45/06 , C07B2200/05 , C07D277/28 , C07D277/30 , C07D417/14 , G01N33/58 , A61K2300/00
摘要： The present application provides for a compound of Formula IV, or a pharmaceutically acceptable salt, solvate, and/or ester thereof, compositions containing such compounds, therapeutic methods that include the administration of such compounds, and therapeutic methods and include the administration of such compounds with at least one additional therapeutic agent.
摘要翻译： 本申请提供式IV化合物或其药学上可接受的盐，溶剂合物和/或酯，含有这些化合物的组合物，包括施用这些化合物的治疗方法和治疗方法，包括给予这些化合物 与至少一种另外的治疗剂。
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公开(公告)号：US20060128692A1
公开(公告)日：2006-06-15
申请号：US10511182
申请日：2003-04-25
申请人： James Chen , Xiaowu Chen , Choung Kim , William Lee , Christopher Lee , Peter Nelson , James Tario , Lianhong Xu
发明人： James Chen , Xiaowu Chen , Choung Kim , William Lee , Christopher Lee , Peter Nelson , James Tario , Lianhong Xu
IPC分类号： A61K31/551 , A61K31/444 , A61K31/44 , C07D487/14
CPC分类号： A61K31/66 , A61K31/675 , C07D213/75 , C07D213/85 , C07D231/12 , C07D231/20 , C07D233/42 , C07D239/49 , C07D239/80 , C07D243/04 , C07D265/18 , C07D307/68 , C07D401/06 , C07D403/06 , C07D471/14 , C07D491/04 , C07F9/4006 , C07F9/58 , C07F9/645 , C07F9/6506 , C07F9/650905 , C07F9/650947 , C07F9/6512 , C07F9/65128 , C07F9/65335 , C07F9/65515 , C07F9/65583 , C07F9/6561 , C12N9/16 , C12Q1/18 , C12Q1/37 , C12Q1/44 , C40B40/04 , G01N33/5038 , G01N2333/16 , G01N2500/04
摘要： Phosphorus-substituted imidazole compounds with anti-HIV properties having use as therapeutics and for other industrial purposes are disclosed. The compositions inhibit reverse transcriptase activity and are useful therapeutically for the inhibition of such enzymes, as well as in assays for the detection of such enzymes.
摘要翻译： 公开了具有用作治疗剂和其它工业目的的具有抗HIV性质的磷取代的咪唑化合物。 组合物抑制逆转录酶活性，并且可用于抑制这些酶以及用于检测这些酶的测定中。
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