发明授权
- 专利标题: Antisense inhibition of integrin .alpha.4 expression
- 专利标题(中): 整合素α4表达的反义抑制
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申请号: US166203申请日: 1998-10-05
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公开(公告)号: US5968826A公开(公告)日: 1999-10-19
- 发明人: C. Frank Bennett , Thomas P. Condon , Lex M. Cowsert
- 申请人: C. Frank Bennett , Thomas P. Condon , Lex M. Cowsert
- 申请人地址: CA Carlsbad
- 专利权人: Isis Pharmaceuticals Inc.
- 当前专利权人: Isis Pharmaceuticals Inc.
- 当前专利权人地址: CA Carlsbad
- 主分类号: C12N15/09
- IPC分类号: C12N15/09 ; A61K31/7115 ; A61K31/712 ; A61K31/7125 ; A61K38/00 ; A61K48/00 ; A61P1/00 ; A61P1/16 ; A61P3/00 ; A61P11/06 ; A61P25/28 ; A61P29/00 ; A61P35/00 ; A61P35/04 ; A61P37/06 ; A61P43/00 ; C07H21/04 ; C12N15/113 ; C12Q1/02 ; C12Q1/68 ; C12N15/00
摘要:
Compositions and methods are provided for modulating the expression of integrin .alpha.4. Antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding integrin .alpha.4 are preferred. Methods of using these compounds for modulating integrin .alpha.4 expression and for treatment of diseases associated with expression of integrin .alpha.4 are also provided.
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