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公开(公告)号：US06258790B1
公开(公告)日：2001-07-10
申请号：US09377309
申请日：1999-08-19
IPC分类号： C12N500
CPC分类号： C12N15/1138 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/334 , C12N2310/341 , C12N2310/346 , C12N2310/3525
摘要： Compositions and methods are provided for modulating the expression of integrin &agr;4. Antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding integrin &agr;4 are preferred. Methods of using these compounds for modulating integrin &agr;4 expression and for treatment of diseases associated with expression of integrin &agr;4 are also provided.
摘要翻译： 提供组合物和方法用于调节整联蛋白α4的表达。 优选靶向编码整联蛋白α4的核酸的反义化合物，特别是反义寡核苷酸。 还提供了使用这些化合物调节整联蛋白α4表达和治疗与整联蛋白α4的表达相关的疾病的方法。
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公开(公告)号：US5968826A
公开(公告)日：1999-10-19
申请号：US166203
申请日：1998-10-05
IPC分类号： C12N15/09 , A61K31/7115 , A61K31/712 , A61K31/7125 , A61K38/00 , A61K48/00 , A61P1/00 , A61P1/16 , A61P3/00 , A61P11/06 , A61P25/28 , A61P29/00 , A61P35/00 , A61P35/04 , A61P37/06 , A61P43/00 , C07H21/04 , C12N15/113 , C12Q1/02 , C12Q1/68 , C12N15/00
CPC分类号： C12N15/1138 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/334 , C12N2310/341 , C12N2310/346
摘要： Compositions and methods are provided for modulating the expression of integrin .alpha.4. Antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding integrin .alpha.4 are preferred. Methods of using these compounds for modulating integrin .alpha.4 expression and for treatment of diseases associated with expression of integrin .alpha.4 are also provided.
摘要翻译： 提供了用于调节整联蛋白α4表达的组合物和方法。优选靶向编码整联蛋白α4的核酸的反义化合物，特别是反义寡核苷酸。 还提供了使用这些化合物调节整合素α4表达和治疗与整联蛋白α4表达相关的疾病的方法。
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公开(公告)号：US08916531B2
公开(公告)日：2014-12-23
申请号：US12743797
申请日：2008-11-20
IPC分类号： C12N15/113
CPC分类号： C12N15/113 , C12N15/1138 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3231 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525
摘要： Disclosed herein are antisense compounds and methods for decreasing CD40. Examples of disease conditions that can be ameliorated with the administration of antisense compounds targeted to CD40 include hyperproliferative disorders, graft versus host disease (GVHD), graft rejection, asthma, airway hyperresponsiveness, chronic obstructive pulmonary disease (COPD), multiple sclerosis (MS), systemic lupus erythematosus (SLE), and certain forms of arthritis.
摘要翻译： 本文公开了用于减少CD40的反义化合物和方法。 通过施用靶向CD40的反义化合物可以改善的疾病状况的实例包括过度增殖性疾病，移植物抗宿主病（GVHD），移植物排斥反应，哮喘，气道高反应性，慢性阻塞性肺疾病（COPD），多发性硬化（MS） ，系统性红斑狼疮（SLE）和某些形式的关节炎。
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公开(公告)号：US06372492B1
公开(公告)日：2002-04-16
申请号：US09702251
申请日：2000-10-30
申请人： C. Frank Bennett , Lex M. Cowsert
发明人： C. Frank Bennett , Lex M. Cowsert
IPC分类号： C12N1500
CPC分类号： C12N15/113 , A61K38/00 , A61K48/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of Talin. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Talin. Methods of using these compounds for modulation of Talin expression and for treatment of diseases associated with expression of Talin are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节Talin的表达。 组合物包含靶向编码Talin的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节Talin表达和治疗与Talin表达相关的疾病的方法。
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公开(公告)号：US06277640B1
公开(公告)日：2001-08-21
申请号：US09630706
申请日：2000-07-31
申请人： C. Frank Bennett , Lex M. Cowsert
发明人： C. Frank Bennett , Lex M. Cowsert
IPC分类号： C12N1563
CPC分类号： C12N15/1138 , A61K38/00 , C12N2310/315 , C12N2310/3181 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3521 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for inhibiting the expression of Her-3. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Her-3. Methods of using these compounds for inhibition of Her-3 expression and for treatment of diseases associated with expression of Her-3 are provided.
摘要翻译： 提供反义化合物，组合物和方法用于抑制Her-3的表达。 组合物包含靶向编码Her-3的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物抑制Her-3表达和治疗与Her-3表达相关的疾病的方法。
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公开(公告)号：US06271029B1
公开(公告)日：2001-08-07
申请号：US09428583
申请日：1999-10-27
申请人： C. Frank Bennett , Lex M. Cowsert
发明人： C. Frank Bennett , Lex M. Cowsert
IPC分类号： A61K317088
CPC分类号： C12N15/113 , A61K31/7088 , A61K31/7115 , A61K31/712 , A61K31/7125 , A61K38/00 , C07H21/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of cytohesin-2. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding cytohesin-2. Methods of using these compounds for modulation of cytohesin-2 expression and for treatment of diseases associated with expression of cytohesin-2 are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节细胞色素-2的表达。 组合物包含靶向编码细胞色素-2的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节细胞凋亡蛋白-2表达和治疗与细胞色素-2表达相关疾病的方法。
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公开(公告)号：US6107092A
公开(公告)日：2000-08-22
申请号：US280409
申请日：1999-03-29
IPC分类号： A61K38/00 , C12N15/113 , C07H21/04 , C12N15/09 , C12Q1/68
CPC分类号： C12N15/113 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582
摘要： Antisense compounds, compositions and methods are provided for modulating the function or amount of SRA. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to SRA or nucleic acids encoding SRA. Methods of using these compounds for modulation of SRA levels and for treatment of diseases associated with SRA are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节SRA的功能或量。 组合物包含靶向SRA或编码SRA的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节SRA水平和治疗与SRA相关疾病的方法。
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公开(公告)号：US6077709A
公开(公告)日：2000-06-20
申请号：US163162
申请日：1998-09-29
IPC分类号： C07H21/04 , A61K31/7088 , A61K31/712 , A61K48/00 , A61P35/00 , C07H21/00 , C12P21/04 , C07H21/02 , C12Q1/68
CPC分类号： C07H21/00 , C07B2200/11
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of Survivin. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Survivin. Methods of using these compounds for modulation of Survivin expression and for treatment of diseases associated with expression of Survivin are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节存活蛋白的表达。 组合物包含靶向编码存活蛋白的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节存活蛋白表达和治疗与存活蛋白表达相关的疾病的方法。
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公开(公告)号：US06004814A
公开(公告)日：1999-12-21
申请号：US161244
申请日：1998-09-25
申请人： C. Frank Bennett , Lex M. Cowsert
发明人： C. Frank Bennett , Lex M. Cowsert
IPC分类号： C12N15/113 , C07H21/04 , C07H21/02 , C12N15/11
CPC分类号： C12N15/1138 , C12N2310/315 , C12N2310/321 , C12N2310/334
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of CD71. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding CD71. Methods of using these compounds for modulation of CD71 expression and for treatment of diseases associated with expression of CD71 are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节CD71的表达。 组合物包含靶向编码CD71的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节CD71表达和治疗与CD71表达相关的疾病的方法。
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公开(公告)号：US5985663A
公开(公告)日：1999-11-16
申请号：US200141
申请日：1998-11-25
申请人： C. Frank Bennett , Lex M. Cowsert
发明人： C. Frank Bennett , Lex M. Cowsert
CPC分类号： C12N15/1136 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of Interleukin-15. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Interleukin-15. Methods of using these compounds for modulation of Interleukin-15 expression and for treatment of diseases associated with expression of Interleukin-15 are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节白介素-15的表达。 组合物包含靶向编码白介素-15的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节白细胞介素-15表达和治疗与白介素-15表达相关疾病的方法。
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