发明授权
- 专利标题： Anti-.alpha.V-integrin monoclonal antibody
- 专利标题（中）： 抗αV-整联蛋白单克隆抗体
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申请号： US574699申请日： 1995-12-19
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公开(公告)号： US5985278A公开(公告)日： 1999-11-16
- 发明人: Francesc Mitjans , Jaume Piulats , Elisabet Rosell , Jaume Adan , Simon Goodman , Diane Hahn
- 申请人： Francesc Mitjans , Jaume Piulats , Elisabet Rosell , Jaume Adan , Simon Goodman , Diane Hahn
- 申请人地址： DEX
- 专利权人： Merck Patent Gesellschaft mit Beschrankter Haftung
- 当前专利权人： Merck Patent Gesellschaft mit Beschrankter Haftung
- 当前专利权人地址： DEX
- 优先权： EPX94120165 19941220
- 主分类号： C12N15/02
- IPC分类号： C12N15/02 ; A61K38/00 ; A61K39/00 ; A61K39/395 ; A61P35/00 ; C07K16/00 ; C07K16/18 ; C07K16/28 ; C12N5/00 ; C12N5/10 ; C12N5/12 ; C12N5/20 ; C12N15/06 ; C12N15/13 ; C12N15/16 ; C12P21/08 ; C12R1/91 ; G01N33/00 ; G01N33/574 ; G01N33/577
摘要：
The invention relates to a novel monoclonal antibody, a hybridoma cell line producing said antibody, DNA sequences coding for said antibody, and amino acid sequences. The monoclonal antibody, a preferred embodiment of which is named 17E6, has the following properties:reacting only with the .alpha.V-chain of human .alpha.V-integrins,blocking the attachment to the integrin substrate of the .alpha.V-integrin bearing cell,triggering reversal of established cell matrix interaction caused by .alpha.V-integrins,blocking tumor development, andshowing no cytotoxic activity.
公开/授权文献
- US4019936A Method for flooring on a closed underlayer 公开/授权日：1977-04-26
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