发明授权
- 专利标题： Cryptophycins from synthesis
- 专利标题（中）： 来自合成的半胱氨酸
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申请号： US400057申请日： 1995-03-07
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公开(公告)号： US06013626A公开(公告)日： 2000-01-11
- 发明人: Richard E. Moore , Marcus A. Tius , Russell A. Barrow , Jian Liang , Thomas H. Corbett , Frederick A. Valeriote , Trimurtulu Golakoti , Thomas K. Hemscheidt
- 申请人： Richard E. Moore , Marcus A. Tius , Russell A. Barrow , Jian Liang , Thomas H. Corbett , Frederick A. Valeriote , Trimurtulu Golakoti , Thomas K. Hemscheidt
- 申请人地址： HI Honolulu MI Detroit
- 专利权人： The University of Hawaii,Wayne State University
- 当前专利权人： The University of Hawaii,Wayne State University
- 当前专利权人地址： HI Honolulu MI Detroit
- 主分类号： C12P13/00
- IPC分类号： C12P13/00 ; A61K31/195 ; A61K31/215 ; A61K31/335 ; A61K31/336 ; A61K31/34 ; A61K31/341 ; A61K31/395 ; A61K38/43 ; A61K45/00 ; A61P35/00 ; A61P35/02 ; A61P43/00 ; C07C237/22 ; C07D273/00 ; C07D273/08 ; C07D303/36 ; C07D307/20 ; C07D413/06 ; C07J21/00 ; C12P21/04 ; A61K38/00 ; A61K38/12 ; C07K5/12
摘要：
A cryptophycin compound is provided having the structure: ##STR1## Further provided are methods of producing cryptophycins by total synthesis and methods of using cryptophycins in pharmaceuticals. It is a further object of this invention to use cryptophycins to inhibit the proliferation of mammalian cells. Moreover, methods of using cryptophycins to treat neoplasia is also provided.
公开/授权文献
- US4927902A Polythiols and use as epoxy resin curing agents 公开/授权日：1990-05-22
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