发明授权
- 专利标题： Human CNP gene and precursor protein
- 专利标题（中）： 人CNP基因和前体蛋白
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申请号： US765830申请日： 1991-09-26
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公开(公告)号： US6034231A公开(公告)日： 2000-03-07
- 发明人: Shoji Tanaka , Kayoko Fuchimura , Yasunori Tawaragi , Hisayuki Matsuo , Kenji Kanagawa , Naoto Minamino
- 申请人： Shoji Tanaka , Kayoko Fuchimura , Yasunori Tawaragi , Hisayuki Matsuo , Kenji Kanagawa , Naoto Minamino
- 申请人地址： JPX Osaka
- 专利权人： Suntory Limited
- 当前专利权人： Suntory Limited
- 当前专利权人地址： JPX Osaka
- 优先权： JPX2-259698 19900927
- 主分类号： C12N15/09
- IPC分类号： C12N15/09 ; A61K38/00 ; A61K38/22 ; A61P7/10 ; C07K14/00 ; C07K14/575 ; C07K14/58 ; C12N15/16 ; C07H17/00
摘要：
The gene of a human CNP (human C-type natriuretic peptide), as well as the hCNP precursor protein that is encoded by said gene. The hCNP precursor is represented by the following amino acid sequence.Met His Leu Ser Gln Leu Leu Ala Cys Ala - Leu Leu Leu Thr Leu Leu Ser Leu Arg Pro - Ser Glu Ala Lys Pro Gly Ala Pro Pro Lys - Val Pro Arg Thr Pro Pro Ala Glu Glu Leu - Ala Glu Pro Gln Ala Ala Gly Gly Gly Gln - Lys Lys Gly Asp Lys Ala Pro Gly Gly Gly - Gly Ala Asn Leu Lys Gly Asp Arg Ser Arg - Leu Leu Arg Asp Leu Arg Val Asp Thr Lys - Ser Arg Ala Ala Trp Ala Arg Leu Leu Gln - Glu His Pro Asn Ala Arg Lys Tyr Lys Gly - Ala Asn Lys Lys Gly Leu Ser Lys Gly Cys - Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser - Met Ser Gly Leu Gly Cys. The hCNP precursor and its derivatives are novel and have natriuretic and hypotensive activities.
公开/授权文献
- US5988318A Connection hook 公开/授权日：1999-11-23
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