发明授权
US6040303A 7-phenyl-1, 4-diazepane compounds, process for their preparation, and
pharmaceutical compositions containing them
有权
7-苯基-1,4-二氮杂环丁烷化合物,其制备方法和含有它们的药物组合物
- 专利标题: 7-phenyl-1, 4-diazepane compounds, process for their preparation, and pharmaceutical compositions containing them
- 专利标题(中): 7-苯基-1,4-二氮杂环丁烷化合物,其制备方法和含有它们的药物组合物
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申请号: US141312申请日: 1998-08-27
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公开(公告)号: US6040303A公开(公告)日: 2000-03-21
- 发明人: Samuel David , Jochen Antel , Reinhard Brueckner , Dieter Ziegler , Christian Eeckhout , Gerhard-Wilhelm Bielenberg , Michael Peck
- 申请人: Samuel David , Jochen Antel , Reinhard Brueckner , Dieter Ziegler , Christian Eeckhout , Gerhard-Wilhelm Bielenberg , Michael Peck
- 申请人地址: DEX Hannover
- 专利权人: Solvay Pharmaceuticals GmbH
- 当前专利权人: Solvay Pharmaceuticals GmbH
- 当前专利权人地址: DEX Hannover
- 优先权: DEX19737334 19970827
- 主分类号: A61K31/55
- IPC分类号: A61K31/55 ; A61P1/00 ; A61P43/00 ; C07D243/08
摘要:
Neurokinin-antagonistic compounds corresponding to formula I: ##STR1## in which R.sup.1 is hydrogen or lower alkyl,R.sup.2 is hydrogen, lower alkyl, lower alkoxy, halogen or trifluoromethyl, andR.sup.3 is hydrogen, lower alkyl, lower alkoxy, halogen or trifluoromethyl, orR.sup.2 and R.sup.3 together are alkylenedioxy with 1 to 2 carbon atoms, bonded to adjacent carbon atoms of the phenyl ring,R.sup.4 is hydrogen, lower alkyl, lower alkoxy, halogen or trifluoromethyl, andR.sup.5 is hydrogen, lower alkyl, lower alkoxy, halogen or trifluoromethyl, orR.sup.4 and R.sup.5 together are alkylenedioxy with 1 to 2 carbon atoms, bonded to adjacent carbon atoms of the phenyl ring,R.sup.6 is lower alkyl, halogen or trifluoromethyl,R.sup.7 is lower alkyl, halogen or trifluoromethyl,A is a --(CH.sub.2).sub.n -- group in which n represents an integer from 1 to 3, or an --NH--(CH.sub.2).sub.m -- group in which m represents an integer from 2 to 3, andB is an alkylene chain with 1 to 3 carbon atoms optionally substituted by lower alkyl,and physiologically acceptable salts thereof and processes for the preparation of these compounds.
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