发明授权
US6080870A Biaryl substituted imidazole compounds useful as farnesyl-protein
transferase inhibitors
失效
可用作法呢基 - 蛋白转移酶抑制剂的二芳基取代的咪唑化合物
- 专利标题： Biaryl substituted imidazole compounds useful as farnesyl-protein transferase inhibitors
- 专利标题（中）： 可用作法呢基 - 蛋白转移酶抑制剂的二芳基取代的咪唑化合物
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申请号： US155663申请日： 1998-10-01
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公开(公告)号： US6080870A公开(公告)日： 2000-06-27
- 发明人: Neville J. Anthony , Robert P. Gomez , Gerald E. Stokker , John S. Wai , Theresa M. Williams , Wasyl Halczenko , John H. Hutchinson , Steven D. Young , Kelly M. Solinsky
- 申请人： Neville J. Anthony , Robert P. Gomez , Gerald E. Stokker , John S. Wai , Theresa M. Williams , Wasyl Halczenko , John H. Hutchinson , Steven D. Young , Kelly M. Solinsky
- 申请人地址： NJ Rahway
- 专利权人： Merck & Co., Inc.
- 当前专利权人： Merck & Co., Inc.
- 当前专利权人地址： NJ Rahway
- 主分类号： C07D233/54
- IPC分类号： C07D233/54 ; C07D233/64 ; C07D233/66 ; C07D233/70 ; C07D403/10 ; C07D403/14 ; C07D233/30 ; A61K31/4164 ; A61K31/4174 ; C07D233/32
摘要：
The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras.
公开/授权文献
- US5342833A Vitamin D3 analogs 公开/授权日：1994-08-30
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