发明授权
- 专利标题: Amino acid derivatives, pharmaceutical compositions containing these compounds and processes for preparing them
- 专利标题(中): 氨基酸衍生物,含有这些化合物的药物组合物及其制备方法
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申请号: US950113申请日: 1997-10-14
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公开(公告)号: US6114390A公开(公告)日: 2000-09-05
- 发明人: Wolfhard Engel , Wolfgang Eberlein , Klaus Rudolf , Henri Doods , Heike-Andrea Wieland , Klaus-Dieter Willim , Michael Entzeroth , Wolfgang Wienen
- 申请人: Wolfhard Engel , Wolfgang Eberlein , Klaus Rudolf , Henri Doods , Heike-Andrea Wieland , Klaus-Dieter Willim , Michael Entzeroth , Wolfgang Wienen
- 申请人地址: DEX Biberach
- 专利权人: Karl Thomae GmbH
- 当前专利权人: Karl Thomae GmbH
- 当前专利权人地址: DEX Biberach
- 主分类号: A61K38/00
- IPC分类号: A61K38/00 ; C07C257/18 ; C07C275/24 ; C07C275/56 ; C07C279/14 ; C07C279/24 ; C07C279/36 ; C07C307/06 ; C07C311/35 ; C07D209/08 ; C07D209/18 ; C07D209/24 ; C07D209/42 ; C07D209/44 ; C07D223/20 ; C07D233/26 ; C07D233/36 ; C07D233/72 ; C07D233/88 ; C07D235/06 ; C07D235/08 ; C07D239/46 ; C07D249/14 ; C07D271/06 ; C07D307/85 ; C07K5/078 ; A61K31/17 ; C07C275/14
摘要:
NPY-antagonistic compounds of the formula ##STR1## Exemplary are: (A) (R)-N-[[4-(Aminocarbonylaminomethyl)phenyl]methyl]-N.sup.2 -bis(4-hydroxyphenyl)acetyl]-argininamide-trifluoracetate;(B) (R)-N-[[4-(Aminocarbonylaminomethyl)phenyl]methyl]-N.sup.2 -[bis(4-chlorphenyl)acetyl]-argininamide-trifluoracetate;(C) (R)-N-[[4-Aminocarbonylaminomethyl)phenyl]methyl]-N.sup.2 -(diphenylacetyl)-argininamide-trifluoracetate;(D) (R)-N.sup.2 -(Diphenylacetyl)-N-[[4-(ethoxycarbonylmethylamino-carbonylaminomethyl)phenyl]methyl]-argininamide-trifluoroacetate;(E) (R,S)-N.sup.5 -(Aminoiminomethyl)-N.sup.2 -(diphenylacetyl)-N-[(4-hy-droxyphenyl)methyl]-N.sup.5 -methyl-ornithinamide-hydrochloride;(F) (R)-N-[[4-(Aminocarbonylmethyl)phenyl]methyl]-N.sup.2 -(diphenyl-acetyl)-argininamide-diacetate;(G) (R)-N.sup.2 -(Diphenylacetyl)-N-[[4-(ethylaminocarbonylamino-methyl)-phenyl]methyl]-argininamide-bis-(trifluoroacetate); and,(H) (R)-N.sup.2 -(Diphenylacetyl)-N-[[4-(ethoxycarbonylamino-carbonylaminomethyl)phenyl]methyl]-argininamide-trifluoroacetate.
公开/授权文献
- US5496288A Protective cap for hypodermic syringe 公开/授权日:1996-03-05