发明授权
US6121056A Random detection of antigens with antibodies immobilized on soluble
submicron particles
失效
用固定在可溶性亚微米颗粒上的抗体随机检测抗原
- 专利标题: Random detection of antigens with antibodies immobilized on soluble submicron particles
- 专利标题(中): 用固定在可溶性亚微米颗粒上的抗体随机检测抗原
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申请号: US226172申请日: 1994-04-12
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公开(公告)号: US6121056A公开(公告)日: 2000-09-19
- 发明人: Fred Moll, III , Charles Ferzli , Spencer H. Lin , Pratap Singh
- 申请人: Fred Moll, III , Charles Ferzli , Spencer H. Lin , Pratap Singh
- 申请人地址: IL Deerfield
- 专利权人: Dade Behring Inc.
- 当前专利权人: Dade Behring Inc.
- 当前专利权人地址: IL Deerfield
- 主分类号: G01N33/543
- IPC分类号: G01N33/543 ; G01N33/545 ; G01N33/547 ; G01N33/552
摘要:
Methods, compositions and articles of manufacture are provided for conducting specific binding assays to determine the concentration or presence of at least one analyte in a sample. At least two dendrimer-reagent preparations with different analyte specificities may be immobilized on a solid phase. Alternatively, at least one dendrimer-reagent preparation having multiple specificities may be immobilized on a solid phase. Immobilization is facilitated by coupling specific binding assay reagents such as polypeptide receptors or analytes with water soluble polymers. Such water soluble polymers, for example star polymers such as dendrimers, provide production advantages of lot-to-lot uniformity and homogeneity, and can enhance sensitivity due to low non-specific binding to the solid phase.
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