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    Process for purification of free bio-amino acids
    6.
    发明授权
    Process for purification of free bio-amino acids 有权
    纯化游离生物氨基酸的方法

    公开(公告)号：US09266818B2

    公开(公告)日：2016-02-23

    申请号：US14376631

    申请日：2013-02-08

    申请人： Harsh Pratap Singh ,  Ajay Rana

    发明人： Harsh Pratap Singh ,  Ajay Rana

    IPC分类号： C07C227/40 ,  C07C237/06

    CPC分类号： C07C227/40 ,  C07C237/06

    摘要： The present invention relates to a green process for purification of free bio amino acids from plant parts, particularly tea leaves and shoots. The invention more particularly relates to an organic solvent free, fast and economical process for purification of natural amino acids on large scale without using any chemical, acid or alkali substance. The invention also relates to a process for purification of bio amino acids from plant and plant parts (renewable bioresources) which are rich in free amino acids.

    摘要翻译： 本发明涉及从植物部分，特别是茶叶和芽中纯化游离生物氨基酸的绿色方法。 本发明更具体地涉及一种无有机溶剂，快速且经济的大规模纯化天然氨基酸的方法，而不使用任何化学，酸或碱物质。 本发明还涉及从富含游离氨基酸的植物和植物部分（可再生生物资源）纯化生物氨基酸的方法。

    WDR13 as a novel biomarker useful for treating diabetes and cancer
    7.
    发明授权
    WDR13 as a novel biomarker useful for treating diabetes and cancer 有权
    WDR13作为可用于治疗糖尿病和癌症的新型生物标志物

    公开(公告)号：US09198986B2

    公开(公告)日：2015-12-01

    申请号：US14116539

    申请日：2012-04-27

    申请人： Satish Kumar ,  Vijay Pratap Singh

    发明人： Satish Kumar ,  Vijay Pratap Singh

    IPC分类号： C12N15/00 ,  A61K49/00 ,  A01K67/027 ,  C07K14/47

    CPC分类号： A61K49/0008 ,  A01K67/0276 ,  A01K2217/072 ,  A01K2227/105 ,  A01K2267/0331 ,  A01K2267/0362 ,  C07K14/47 ,  C07K2319/41 ,  C07K2319/43 ,  C12N2710/10043

    摘要： WD-repeat proteins are very diverse, yet these are structurally related proteins that participate in a wide range of cellular functions. WDR13, a member of this family, is conserved from fishes to humans and localizes into the nucleus. To understand the in vivo function(s) of Wdr13 gene, we have created and characterized a mutant mouse strain lacking this gene. The mutant mice had higher serum insulin levels and increased pancreatic islet mass as a result of the enhanced beta cell proliferation. While a known cell cycle inhibitor, p21, was down regulated in the mutant islets overexpression of WDR13 in the pancreatic MIN6 cell line resulted in upregulation of p21, accompanied by retardation of cell proliferation. We suggest that WDR13 is a novel negative regulator of the pancreatic beta cell proliferation. Co-immunoprecipitation experiments showed that this protein interacts with estrogen receptors and various HDACs. We provide evidence to show that WDR13 can regulate estrogen receptors-mediated transcription both in HDAC-dependent and HDAC-independent manner. Given the higher insulin levels, better glucose clearance and the lack of insulin resistance in WDR13 deficient mice, we propose that this protein may be a potential candidate drug target for ameliorating impaired glucose metabolism in diabetes.

    摘要翻译： WD重复蛋白是非常多样化的，但这些是参与广泛细胞功能的结构相关蛋白。 WDR13，这个家庭的成员，从鱼类保存到人类，并定位到核心。 为了了解Wdr​​13基因的体内功能，我们创建并表征了缺乏该基因的突变小鼠株。 由于增强的β细胞增殖，突变小鼠具有较高的血清胰岛素水平和胰岛素的增加。 虽然已知的细胞周期抑制剂p21在胰岛MIN6细胞系中突变型胰岛过表达WDR13中下调，导致p21上调，伴随着细胞增殖的延迟。 我们建议WDR13是胰腺β细胞增殖的新型负调节因子。 共免疫沉淀实验显示，该蛋白质与雌激素受体和各种HDAC相互作用。 我们提供证据表明，WDR13可以调节雌激素受体介导的转录，无论是HDAC依赖型还是HDAC独立型。 鉴于WDR13缺陷小鼠胰岛素水平升高，葡萄糖清除率更高，胰岛素抵抗不足，我们建议该蛋白可能是改善糖尿病中糖代谢紊乱的潜在候选药物靶点。

    System for pre-mixing in a fuel nozzle
    9.
    发明授权
    System for pre-mixing in a fuel nozzle 有权
    用于在燃料喷嘴中预混合的系统

    公开(公告)号：US08850822B2

    公开(公告)日：2014-10-07

    申请号：US13012746

    申请日：2011-01-24

    申请人： Nishant Govindbhai Parsania ,  Ajay Pratap Singh

    发明人： Nishant Govindbhai Parsania ,  Ajay Pratap Singh

    IPC分类号： F02C1/00 ,  F23R3/36 ,  F23R3/14 ,  F23R3/28

    CPC分类号： F23R3/36 ,  F23C2900/07001 ,  F23R3/14 ,  F23R3/286

    摘要： A system includes a fuel nozzle. The fuel nozzle includes a hub having an axis, a shroud disposed about the hub, an airflow path between the hub and the shroud, multiple vanes extending between the hub and the shroud, and a first fuel path leading to multiple first fuel outlets disposed on the multiple vanes. The fuel nozzle also includes a second fuel path leading to multiple second fuel outlets disposed on at least one of the hub and/or the shroud, wherein the multiple second fuel outlets are disposed at an axial distance upstream from a downstream end of the hub.

    摘要翻译： 系统包括燃料喷嘴。 燃料喷嘴包括具有轴线的轮毂，围绕毂设置的护罩，轮毂和护罩之间的气流路径，在轮毂和护罩之间延伸的多个叶片，以及通向多个第一燃料出口的第一燃料路径， 多叶片。 燃料喷嘴还包括通向设置在轮毂和/或护罩中的至少一个上的多个第二燃料出口的第二燃料通路，其中多个第二燃料出口设置在距毂的下游端的上游轴向距离处。

    MULTI-LEVEL RESERVOIR HISTORY MATCHING
    10.
    发明申请
    MULTI-LEVEL RESERVOIR HISTORY MATCHING 有权
    多层次储层历史匹配

    公开(公告)号：US20140039859A1

    公开(公告)日：2014-02-06

    申请号：US13563270

    申请日：2012-07-31

    申请人： Marko MAUCEC ,  Gustavo CARVAJAL ,  Seyed M. MIRZADEH ,  Ajay Pratap SINGH ,  Hasnain A. KHAN ,  Luigi A. SAPUTELLI

    发明人： Marko MAUCEC ,  Gustavo CARVAJAL ,  Seyed M. MIRZADEH ,  Ajay Pratap SINGH ,  Hasnain A. KHAN ,  Luigi A. SAPUTELLI

    IPC分类号： G06G7/48

    CPC分类号： E21B43/00 ,  G01V99/00

    摘要： The present disclosure describes systems and methods for performing multi-level reservoir history matching. At least some illustrative embodiments include a method that includes generating a first history-matched model using at least one updated model parameter derived from one or more existing model parameters, generating a set of second history-matched models by applying a probabilistic inversion to the first history-matched model, and deriving a set of third history-matched models from the set of second history-matched models. The method further includes generating dynamic simulation realization sets using each of the set of third history-matched models, ranking each of the set of third history-matched models based at least in part on the dynamic simulation realization sets, and presenting a production forecast to a user based on the highest ranked third history-matched models.

    摘要翻译： 本公开描述了用于执行多级油藏历史匹配的系统和方法。 至少一些说明性实施例包括一种方法，其包括使用从一个或多个现有模型参数导出的至少一个更新模型参数生成第一历史匹配模型，通过将概率反演应用于第一历史匹配模型 历史匹配模型，并从一组第二历史匹配模型中推导出一组第三历史匹配模型。 所述方法还包括使用所述一组第三历史匹配模型中的每一者生成动态模拟实现集合，至少部分地基于所述动态模拟实现集合对所述第三历史匹配模型集合中的每一者进行排序，并将生产预测呈现给 基于最高排名第三的历史匹配模型的用户。