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    METHODS FOR DETECTION OF CYCLOSPORIN A
    1.
    发明申请
    METHODS FOR DETECTION OF CYCLOSPORIN A 审中-公开
    检测环磷酰胺A的方法

    公开(公告)号：US20090170218A1

    公开(公告)日：2009-07-02

    申请号：US11968349

    申请日：2008-01-02

    Applicant: Yi Feng Zheng ,  Deb K. Vickery ,  Susan C. Swann

    Inventor： Yi Feng Zheng ,  Deb K. Vickery ,  Susan C. Swann

    IPC: G01N33/566 ,  C07D259/00

    CPC classification number: G01N33/9493 ,  C07K7/645 ,  G01N33/542

    Abstract: Methods and reagents are disclosed for determining the presence and/or amount of cyclosporin A in a medium suspected of containing cyclosporin A. In the method a combination is provided in a medium. The combination comprises (i) the sample, (ii) a first member of a signal producing system (sps) associated with a first support wherein the first sps member is capable of activating a second member of the sps and wherein the first support is associated with a first member of a specific binding pair, and (iii) the second sps member associated with a second support wherein the second sps member is activatable by the first sps member. The second support comprises either (I) cyclosporin C or cyclosporin A and the combination further comprises a conjugate of an antibody for cyclosporin A and a second member of the specific binding pair or (II) antibody for cyclosporin A and the combination further comprises a conjugate of cyclosporin A and a second member of the specific binding pair. The combination is subjected to conditions for binding of cyclosporin A to the antibody for cyclosporin A. The first sps member is activated and the amount of signal generated by the second sps member is detected. The amount of signal is related to the presence and/or amount of cyclosporin A in the sample.

    Abstract translation: 公开了用于确定怀疑含有环孢菌素A的培养基中环孢菌素A的存在和/或量的方法和试剂。在该方法中，在培养基中提供组合。 该组合包括（i）样品，（ii）与第一支撑件相关联的信号产生系统（sps）的第一构件，其中第一sp构件能够激活sp的第二构件，并且其中第一支撑件相关联 具有特定装订对的第一成员，以及（iii）与第二支撑件相关联的第二sps构件，其中第二sp构件可由第一sp构件激活。 第二种载体包括（I）环孢菌素C或环孢菌素A，并且该组合还包含环孢菌素A的抗体和特异性结合对的第二个成员或环孢菌素A的（II）抗体的缀合物，并且该组合还包含缀合物 的环孢菌素A和特异性结合对的第二个成员。 该组合经受环孢菌素A与环孢菌素A的抗体结合的条件。第一个sps成员被激活，并且检测由第二个sps成员产生的信号量。 信号量与样品中环孢菌素A的存在和/或量有关。

    Micro-sample cup rack adapter
    2.
    发明申请
    Micro-sample cup rack adapter 有权
    微型样品杯架适配器

    公开(公告)号：US20080056956A1

    公开(公告)日：2008-03-06

    申请号：US11470138

    申请日：2006-09-05

    Applicant: Tumkur R. Vijay ,  David R. Thompson

    Inventor： Tumkur R. Vijay ,  David R. Thompson

    IPC: B01L11/00

    CPC classification number: B01L9/06 ,  B01L3/5082 ,  B01L2200/023 ,  G01N35/026 ,  G01N35/028 ,  Y10T436/11

    Abstract: A small sample cup rack adapter having a spring biased plunger moveably disposed within a generally cylindrical outer body, with the plunger adapted to support a small sample cup within the outer body. After initial contact between an aspiration probe and the bottom of the small sample cup, the probe may be lowered an additional distance, minimizing the “dead volume” of sample.

    Abstract translation: 小样品杯架适配器具有可移动地设置在大致圆柱形外主体内的弹簧偏置柱塞，其中柱塞适于在外体内支撑小样品杯。 在吸液探针和小样品杯底部初次接触之后，探针可以被降低一段距离，使样品的“死体积”最小化。

    Compositions and methods for detection of sirolimus
    7.
    发明授权
    Compositions and methods for detection of sirolimus 有权
    用于检测西罗莫司的组合物和方法

    公开(公告)号：US07189582B2

    公开(公告)日：2007-03-13

    申请号：US11116928

    申请日：2005-04-27

    Applicant: Jian Chen ,  Holger Keim ,  Hshiou-ting Liu ,  Yi Feng Zheng ,  Yali Yang ,  Cathy K. Worley

    Inventor： Jian Chen ,  Holger Keim ,  Hshiou-ting Liu ,  Yi Feng Zheng ,  Yali Yang ,  Cathy K. Worley

    IPC: G01N33/532 ,  C07K16/44 ,  C07K1/13 ,  C07D267/00

    CPC classification number: C07K16/44 ,  A61K47/61 ,  A61K47/643 ,  A61K47/646 ,  A61K47/6923 ,  C07D498/18 ,  C07D519/00 ,  G01N33/9493 ,  Y10S436/815 ,  Y10S530/807 ,  Y10T436/13

    Abstract: Compounds are disclosed comprising a moiety, such as a poly(amino acid), a non-poly(amino acid) label moiety, or a non-poly(amino acid) immunogenic carrier, linked to a sirolimus compound at position 26 or at position 32. Such sirolimus compounds comprising an immunogenic carrier can be employed to raise both polyclonal and monoclonal antibodies to the sirolimus compound. Polyclonal antibodies are also disclosed, which are raised against a compound wherein a moiety, such as a poly(amino acid), a non-poly(amino acid) label moiety, or a non-poly(amino acid) immunogenic carrier, is linked to a sirolimus compound at position 32. The above antibodies and sirolimus compounds comprising a label can be used in assays for the detection of sirolimus compounds.

    Abstract translation: 公开了包含部分，例如聚（氨基酸），非聚（氨基酸）标记部分或非聚（氨基酸）免疫原性载体的部分，其连接于位置26或位置的西罗莫司化合物 包含免疫原性载体的这种西罗莫司化合物可用于提高西罗莫司化合物的多克隆和单克隆抗体。 还公开了多克隆抗体，其针对其中部分例如聚（氨基酸），非聚（氨基酸）标记部分或非聚（氨基酸）免疫原性载体连接的化合物产生 至32位的西罗莫司化合物。包含标记的上述抗体和西罗莫司化合物可用于检测西罗莫司化合物。

    Increasing throughput of an automatic clinical analyzer system by partitioning assays according to frequency of requested performance
    8.
    发明授权
    Increasing throughput of an automatic clinical analyzer system by partitioning assays according to frequency of requested performance 有权
    通过根据要求的性能的频率划分分析，增加自动临床分析仪系统的产量

    公开(公告)号：US07101715B2

    公开(公告)日：2006-09-05

    申请号：US10245245

    申请日：2002-09-17

    Applicant: William Jackson Devlin, Sr. ,  David R. Thompson

    Inventor： William Jackson Devlin, Sr. ,  David R. Thompson

    IPC: G01N35/02 ,  G01N33/50

    CPC classification number: G01N35/025 ,  G01N35/0092 ,  G01N2035/0093 ,  Y10T436/11 ,  Y10T436/115831

    Abstract: A dual analyzer system comprising at least two analyzers where samples to be tested are partitioned into three groups in accord with the frequency the test assays are requested. One analyzer performs a portion of the most frequently menu assays and all of a first subgroup of less frequently requested assays. The second analyzer performs a similar portion of the most frequently menu assays and all of a second subgroup of less frequently requested assays. The first of the analyzers is not equipped to perform any of the second subgroup of assays and the second analyzer is not be equipped to perform any of the second subgroup of assays.

    Abstract translation: 一种双分析仪系统，包括至少两个分析器，其中待测试的样品根据要求的测试测定的频率被分成三组。 一个分析仪执行最频繁的菜单测定的一部分和所有不太常见的测定的第一个亚组。 第二个分析仪执行最频繁的菜单测定的类似部分，以及所有不太常见的测定的第二个亚组。 第一个分析仪没有配备进行任何第二个分组分析，第二个分析仪不配备执行任何第二个测试亚组。

    Assay for entactogens
    9.
    发明授权
    Assay for entactogens 有权
    检测细菌

    公开(公告)号：US06991911B2

    公开(公告)日：2006-01-31

    申请号：US10736005

    申请日：2003-12-15

    Applicant: Yi Feng Zheng ,  Hshiou-ting Liu

    Inventor： Yi Feng Zheng ,  Hshiou-ting Liu

    IPC: G01N33/53 ,  G01N33/531 ,  C07K16/00 ,  C07K17/02 ,  C07D317/58

    CPC classification number: C07D405/12 ,  C07D317/58 ,  C07K16/44 ,  G01N33/946 ,  Y10S435/961 ,  Y10S435/975

    Abstract: Methods, compositions and kits are disclosed. The methods are directed to determining the presence of entactogen analytes such as, for example, 3,4-methylenedioxyamphetamine (MDA), 3,4-methylenedioxy-methamphetamine (MDMA), 3,4-methylenedioxy-ethylamphetamine (MDEA) and 4-hydroxy-3-methoxy-methamphetamine (HMMA). The method comprises providing in combination in a medium (i) a sample suspected of containing the compound and (ii) an antibody raised against a compound of Formula I that comprises a protein. The medium is examined for the presence a complex comprising the compound and the antibody where the presence of such as complex indicates the presence of the compound in the sample. In one aspect of the above embodiment, the combination further comprises a label conjugate of the compound Formula I.

    Abstract translation: 公开了方法，组合物和试剂盒。 该方法涉及确定活性成分分析物的存在，例如3,4-亚甲二氧基苯丙胺（MDA），3,4-亚甲二氧基 - 甲基苯丙胺（MDMA），3,4-亚甲二氧基 - 乙基苯丙胺（MDEA）和4- 羟基-3-甲氧基 - 甲基苯丙胺（HMMA）。 该方法包括在介质中提供（i）怀疑含有该化合物的样品和（ii）针对包含蛋白质的式I化合物产生的抗体。 检查介质是否存在包含化合物和抗体的复合物，其中诸如复合物的存在表明样品中存在化合物。 在上述实施方案的一个方面，组合还包含化合物式I的标记缀合物。

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