发明授权
US06124323A 4-substituted piperidine analogs and their use as subtype selective NMDA
receptor antagonists
失效
4-取代的哌啶类似物及其作为亚型选择性NMDA受体拮抗剂的用途
- 专利标题： 4-substituted piperidine analogs and their use as subtype selective NMDA receptor antagonists
- 专利标题（中）： 4-取代的哌啶类似物及其作为亚型选择性NMDA受体拮抗剂的用途
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申请号： US091598申请日： 1998-09-16
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公开(公告)号： US06124323A公开(公告)日： 2000-09-26
- 发明人: Christopher F. Bigge , Po-Wai Yuen , Sui Xiong Cai , Eckard Weber , Richard Woodward , Nancy C. Lan , Zhang-Lin Zhou , John F. W. Keana , Anthony P. Guzikowski
- 申请人： Christopher F. Bigge , Po-Wai Yuen , Sui Xiong Cai , Eckard Weber , Richard Woodward , Nancy C. Lan , Zhang-Lin Zhou , John F. W. Keana , Anthony P. Guzikowski
- 申请人地址： NJ Morris Plains CA Irvine
- 专利权人： Warner-Lambert Company,Cocensys, Incorporated
- 当前专利权人： Warner-Lambert Company,Cocensys, Incorporated
- 当前专利权人地址： NJ Morris Plains CA Irvine
- 主分类号： C07D211/14
- IPC分类号： C07D211/14 ; C07D211/18 ; C07D211/22 ; C07D211/28 ; C07D211/30 ; C07D211/38 ; C07D211/42 ; C07D211/44 ; C07D211/46 ; C07D211/48 ; C07D211/64 ; C07D401/04 ; C07D401/06 ; C07D401/12 ; C07D405/04 ; C07D405/12 ; C07D413/12 ; C07D417/12 ; C07D487/04 ; A01N43/40 ; C07D211/20 ; C07D211/26 ; C07D211/60
摘要：
Novel 4-substituted piperidine analogs, pharmaceutical compositions containing the same and the method of using 4-substituted piperidine analogs are selective active antagonists of N-methyl-D-aspartate (NMDA) receptor subtypes for treating conditions such as stroke, cerebral ischemia, central nervous system trauma, hypoglycemia, psychosis, anxiety, migraine headaches, glaucoma, CMV retinitis, aminoglycoside antibiotics-induced hearing loss, convulsions, chronic pain, opioid tolerance or withdrawal, urinary incontinence or neurodegenerative disorders, such as lathyrism, Alzheimer's Disease, Parkinsonism and Huntington's Disease are described.
公开/授权文献
- US4329576A Data storage means and reading system therefor 公开/授权日：1982-05-11
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