发明授权
- 专利标题： Antigenic preparations and the isolation of such preparations
- 专利标题（中）： 抗原制剂和这些制剂的分离
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申请号： US470590申请日： 1995-06-07
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公开(公告)号： US6127151A公开(公告)日： 2000-10-03
- 发明人: Pavel Novotny, deceased , by Jaroslava Novotny, administrator , Juan Antonio Montaraz Crespo , Juraj Ivanyi
- 申请人： Pavel Novotny, deceased , by Jaroslava Novotny, administrator , Juan Antonio Montaraz Crespo , Juraj Ivanyi
- 申请人地址： GBX Leatherhead
- 专利权人： Medeva Pharma Limited
- 当前专利权人： Medeva Pharma Limited
- 当前专利权人地址： GBX Leatherhead
- 优先权： GBX8412207 19840512
- 主分类号： A61K39/095
- IPC分类号： A61K39/095 ; A61K31/00 ; A61K39/00 ; A61K39/02 ; A61K39/085 ; A61K39/09 ; A61K39/10 ; A61P31/00 ; A61P31/04 ; C07K1/00 ; C07K1/18 ; C07K1/22 ; C07K14/235 ; C12N9/88 ; C12P21/00 ; C12P21/04 ; C12N13/00
摘要：
A method of deriving an antigen from Bordetella pertussis, wherein the antigen is characterized by the following features: a relative molecular weight of about 67,000 to 73,000 as determined by 12%(w/w) polyacrylamide gel electrophoresis and a proline:glutamic acid ratio of about 1:1 as determined by amino acid analysis. The method comprises: (a) culturing Bordetella pertussiscells; (b) treating the culture of (a) to obtain an outer membrane fraction; and (c) isolating the antigen from the outer membrane fraction of (b).
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