发明授权
- 专利标题： Mono- or polyenic carboxylic acid derivatives
- 专利标题（中）： 单或多元羧酸衍生物
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申请号： US236644申请日： 1999-01-26
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公开(公告)号： US6133283A公开(公告)日： 2000-10-17
- 发明人: Shigeki Hibi , Kouichi Kikuchi , Hiroyuki Yoshimura , Mitsuo Nagai , Katsuya Tagami , Shinya Abe , Ieharu Hishinuma , Junichi Nagakawa , Norimasa Miyamoto , Takayuki Hida , Aichi Ogasawara , Seiko Higashi , Kenji Tai , Takashi Yamanaka , Makoto Asada
- 申请人： Shigeki Hibi , Kouichi Kikuchi , Hiroyuki Yoshimura , Mitsuo Nagai , Katsuya Tagami , Shinya Abe , Ieharu Hishinuma , Junichi Nagakawa , Norimasa Miyamoto , Takayuki Hida , Aichi Ogasawara , Seiko Higashi , Kenji Tai , Takashi Yamanaka , Makoto Asada
- 申请人地址： JPX Tokyo
- 专利权人： Eisai Co., Ltd.
- 当前专利权人： Eisai Co., Ltd.
- 当前专利权人地址： JPX Tokyo
- 优先权： JPX6-276287 19941031; JPX7-166120 19950630
- 主分类号： A61P19/02
- IPC分类号： A61P19/02 ; C07C57/03 ; C07C229/44 ; C07D209/08 ; C07D213/69 ; C07D215/12 ; C07D215/14 ; C07D215/18 ; C07D223/16 ; C07D225/06 ; C07D231/12 ; C07D241/38 ; C07D241/42 ; C07D241/46 ; C07D261/18 ; C07D263/32 ; C07D265/36 ; C07D333/76 ; C07D405/14 ; C07D455/04 ; C07D487/04 ; C07D495/04 ; G06F17/30 ; C07D455/06 ; A61K31/44
摘要：
To provide novel compounds relating to retinoid which can substitute for retinoic acid used for preventing and treating several diseases and having antagonism against retinoid. Heterocyclic compounds represented by the general formula (1-I) or physiologically acceptable salts thereof:Z--(CR.sup.3 .dbd.CR.sup.2).sub.n --COOR.sup.1-- (1-I)Compounds represented by the general formula (2-I) or physiologically acceptable salts thereof: ##STR1## The compounds according to the present invention exhibit extremely high ability to bind RARs and are effective for treating various kind of diseases such as abnormality in cornification and rheumatoid arthritis.