发明授权
US6143729A Compounds related to the amidinium family, pharmaceutical compositions
containing same, and uses thereof
有权
与idin族有关的化合物，含有它们的药物组合物及其用途
- 专利标题： Compounds related to the amidinium family, pharmaceutical compositions containing same, and uses thereof
- 专利标题（中）： 与idin族有关的化合物，含有它们的药物组合物及其用途
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申请号： US125825申请日： 1998-09-11
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公开(公告)号： US6143729A公开(公告)日： 2000-11-07
- 发明人: Jean-Marie Lehn , Pierre Lehn , Jean-Pierre Vigneron
- 申请人： Jean-Marie Lehn , Pierre Lehn , Jean-Pierre Vigneron
- 申请人地址： FRX Antony
- 专利权人： Aventis Pharma S.A.
- 当前专利权人： Aventis Pharma S.A.
- 当前专利权人地址： FRX Antony
- 优先权： FRX9602604 19960301; FRX9609557 19960730
- 主分类号： C12N15/09
- IPC分类号： C12N15/09 ; A61K9/127 ; A61K31/575 ; C07C271/60 ; C07J41/00 ; C12N15/88 ; A61K48/00 ; A61K31/70 ; A61K51/00 ; B01J13/02 ; B01J13/04 ; C12N5/00
摘要：
Novel amidinium derivatives of formula (I), wherein R1 is a cholesterol derivative or an alkylamino-NR'R" grouping, and each of R2 and R3 is independently a hydrogen atom or a grouping of formula (II), wherein each of R4 and R5 is independently a hydrogen atom or a grouping of formula (III), are disclosed. The corresponding pharmaceutical compositions, which are particularly useful in gene therapy for transferring therapeutic genes into cells, are also disclosed. ##STR1##
公开/授权文献
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