发明授权
- 专利标题: Fused imidazopyridine derivatives as antihyperlipidemic agents
- 专利标题(中): 融合的咪唑并吡啶衍生物作为抗高血脂药物
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申请号: US09155889申请日: 1998-10-08
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公开(公告)号: US06235731B1公开(公告)日: 2001-05-22
- 发明人: Yumiko Shibouta , Yasuo Sugiyama , Tetsuji Kawamoto , Muneo Takatani
- 申请人: Yumiko Shibouta , Yasuo Sugiyama , Tetsuji Kawamoto , Muneo Takatani
- 优先权: JP8-102303 19960424; JP8-330801 19961211
- 主分类号: A61K31549
- IPC分类号: A61K31549
摘要:
A novel compound of the formula: wherein ring Q is an optionally substituted pyridine ring; One of R0, R1 and R2 is —Y0—Z0, and the other tow groups are a hydrogen, a halogen, an optionally substituted hydroxy group, a hydrocarbon group that may be an optionally substituted hydrocarbon group or an acyl group; Y0 is a bond or an optionally substituted bivalent hydrocarbon group; Z0 is a basic group which may be bonded via oxygen, nitrogen, —CO—, —CS—, —SO2N(R3)— (where R3 is hydrogen or an optionally substituted hydrocarbon group), or S(O)n (wherein n is to 0, 1 or 2); ......... is a single bond or a double bond, or a salt thereof, which has an excellent LDL receptor up-regulating, blood-lipids lowering, blood-sugar lowering and diabetic complication-ameliorating activity.
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