公开(公告)号：US06344453B1

公开(公告)日：2002-02-05

申请号：US09294099

申请日：1999-04-19

申请人： Kozo Shiokawa ,  Shinichi Tsuboi ,  Koichi Moriya ,  Katsuhiko Shibuya

发明人： Kozo Shiokawa ,  Shinichi Tsuboi ,  Koichi Moriya ,  Katsuhiko Shibuya

IPC分类号： A61K31549

CPC分类号： C07D401/06 ,  A01N47/40 ,  A01N51/00 ,  C07D401/14 ,  C07D403/06 ,  C07D405/06 ,  C07D409/06 ,  C07D413/06 ,  C07D417/06 ,  C07D419/06

摘要： Insecticidal heterocyclic compounds of the formula wherein A represents a five-membered or six-membered heteroaryl group containing one to three hetero atoms selected from the group consisting of S, O and N, said heteroaryl group being unsubstituted or substituted by a halogen atom or C1-4 alkyl group, Z represents a three-membered straight chain, each member being selected from the group consisting of CH2—, O, S and N—R2 with at least one of said three members being O, S or N—R2, E represents CH2, O, S or N—R2, wherein R2 represents a hydrogen atom, a C1-4 alkyl group, a C1-4 alkoxy group or the group  wherein R3 represents a hydrogen atom or halogen atom, X represents CH or N, Y represents a nitro group or cyano group, and R1 represents a hydrogen atom or methyl group.

摘要翻译： 甲基脲A的杀虫杂环化合物表示含有一至三个选自S，O和N的杂原子的五元或六元杂芳基，所述杂芳基未被取代或被卤素原子或C1- 4个烷基，Z表示三元直链，每个成员选自CH 2 - ，O，S和N-R 2，所述三个成员中的至少一个为O，S或N-R2，E 表示CH2，O，S或N-R2，其中R2表示氢原子，C1-4烷基，C1-4烷氧基或R3表示氢原子或卤原子的基团，X表示CH或N， Y表示硝基或氰基，R 1表示氢原子或甲基。

公开(公告)号：US06235731B1

公开(公告)日：2001-05-22

申请号：US09155889

申请日：1998-10-08

申请人： Yumiko Shibouta ,  Yasuo Sugiyama ,  Tetsuji Kawamoto ,  Muneo Takatani

发明人： Yumiko Shibouta ,  Yasuo Sugiyama ,  Tetsuji Kawamoto ,  Muneo Takatani

IPC分类号： A61K31549

CPC分类号： C07D513/16

摘要： A novel compound of the formula: wherein ring Q is an optionally substituted pyridine ring; One of R0, R1 and R2 is —Y0—Z0, and the other tow groups are a hydrogen, a halogen, an optionally substituted hydroxy group, a hydrocarbon group that may be an optionally substituted hydrocarbon group or an acyl group; Y0 is a bond or an optionally substituted bivalent hydrocarbon group; Z0 is a basic group which may be bonded via oxygen, nitrogen, —CO—, —CS—, —SO2N(R3)— (where R3 is hydrogen or an optionally substituted hydrocarbon group), or S(O)n (wherein n is to 0, 1 or 2); ......... is a single bond or a double bond, or a salt thereof, which has an excellent LDL receptor up-regulating, blood-lipids lowering, blood-sugar lowering and diabetic complication-ameliorating activity.

摘要翻译： 一种下式的新化合物：其中环Q是任选取代的吡啶环; R 0，R 1和R 2之一是-YO-Z 0，其它的三个基团是氢，卤素，任选取代的羟基，烃 可以是任意取代的烃基或酰基的基团; Y 0是一个键或任意取代的二价烃基; Z 0是可以通过氧，氮，-CO-，-CS-，-SO 2 N键合的碱性基团 （R 3） - （其中R 3是氢或任选取代的烃基）或S（O）n（其中n是0,1或2）; .........是单键或 双键或其盐，其具有优异的LDL受体上调，血脂降低，血糖降低和糖尿病并发症改善活性。