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13 条记录 (耗时 0.019 秒)

    Prophylactic or therapeutic drug for renal diseases
    1.
    发明授权
    Prophylactic or therapeutic drug for renal diseases 失效
    肾病预防或治疗药物

    公开(公告)号：US06319938B1

    公开(公告)日：2001-11-20

    申请号：US09467488

    申请日：1999-12-20

    申请人： Kohei Nishikawa ,  Yumiko Shibouta ,  Keiji Kubo

    发明人： Kohei Nishikawa ,  Yumiko Shibouta ,  Keiji Kubo

    IPC分类号： A61K3141

    CPC分类号： A61K31/4184 ,  A61K31/415 ,  A61K31/4245 ,  Y02A50/395

    摘要： Prophylactic or therapeutic drugs for diabetic nephropathy or glomerulonephritis, comprising, as an active ingredient, a compound or salt thereof represented by formula (I) wherein R1 stands for H or an optionally substituted hydrocarbon residue; R2 stands for an optionally esterified carboxyl group; R3 stands for a group actually or potentially capable of forming an anion; X shows that the phenylene and phenyl groups bind to each other directly or through a spacer having an atomic chain length of two or less; n stands for 1 or 2; ring A stands for a benzene ring having an optional substituent in addition to R2; Y stands for a bond, —O—, —S(O)m—, wherein m stands for 0, 1 or 2, or —N(R4)— wherein R4 stands for H or an optionally substituted alkyl group are disclosed.

    摘要翻译： 糖尿病性肾病或肾小球性肾炎的预防或治疗药物，其包含作为活性成分的由式（I）表示的化合物或其盐，其中R1代表H或任选取代的烃残基; R2代表任选酯化的羧基; R3代表实际上或潜在能够形成阴离子的组; X表示亚苯基和苯基直接或通过原子链长度为2或更小的间隔物彼此结合; n代表1或2; 环A代表除R2之外具有任选取代基的苯环; Y代表键，-O - ， - S（O）m - ，其中m代表0,1或2或-N（R 4） - ，其中R 4代表H或任意取代的烷基。

    Tricyclic compounds, their production and use
    4.
    发明授权
    Tricyclic compounds, their production and use 失效
    三环化合物，其生产和使用

    公开(公告)号：US06251905B1

    公开(公告)日：2001-06-26

    申请号：US09234876

    申请日：1999-01-21

    申请人： Muneo Takatani ,  Yumiko Shibouta ,  Kiminori Tomimatsu ,  Tetsuji Kawamoto

    发明人： Muneo Takatani ,  Yumiko Shibouta ,  Kiminori Tomimatsu ,  Tetsuji Kawamoto

    IPC分类号： C07D40106

    CPC分类号： C07D471/16

    摘要： Tricyclic compound of the formula: wherein ring A is a nitrogen-containing heterocyclic ring, having two nitrogen atoms as the hetero-atoms, which is optionally substituted with oxo or thioxo; ring Q may optionally be substituted; Y is an optionally substituted hydrocarbon group, an optionally substituted hydroxyl group or an optionally substituted mecapto group, excluding for methyl group as Y; R1 is a hydrogen atom, a halogen atom, an optionally substituted hydrocarbon group or an acyl group, or a salt thereof, having excellent PDGF-inhibiting activities, antihypertensive activities, activities of ameliorating renal diseases and activities of lowering lipid level.

    摘要翻译： 下式的三环化合物：其中环A是含氮杂环，具有两个氮原子作为杂原子，其任选被氧代或硫代取代; 环Q可任选被取代; Y是任选取代的烃基，任选取代的羟基或任选取代的mecapto基团，不包括甲基作为Y; R1是具有优异的PDGF抑制活性，抗高血压活性，改善肾脏疾病的活性和降低脂质水平的活性的氢原子，卤素原子，任选取代的烃基或酰基或其盐。

    Method for the treatment of sclerosis of the glomeruli
    5.
    发明授权
    Method for the treatment of sclerosis of the glomeruli 失效
    治疗肾小球硬化症的方法

    公开(公告)号：US5719173A

    公开(公告)日：1998-02-17

    申请号：US696475

    申请日：1996-08-14

    申请人： Kohei Nishikawa ,  Yumiko Shibouta ,  Keiji Kubo

    发明人： Kohei Nishikawa ,  Yumiko Shibouta ,  Keiji Kubo

    IPC分类号： A61K31/415 ,  A61K31/4184 ,  A61K31/4245 ,  A61P3/08 ,  A61P3/10 ,  A61P13/02 ,  A61P15/00 ,  A61P29/00 ,  C07D403/10 ,  C07D413/10 ,  C07D417/10 ,  A61K31/41

    CPC分类号： A61K31/4184 ,  A61K31/415 ,  A61K31/4245

    摘要： This invention relates to prophylactic or therapeutic drug for diabetic nephropathy or glomerulonephritis, comprising, as an active ingredient, a compound or salt thereof represented by general formula (I) ##STR1## wherein R.sup.1 stands for H or an optionally substituted hydrocarbon residue; R.sup.2 stands for an optionally esterified carboxyl group; R.sup.3 stands for a group actually or potentially capable of forming an anion; X shows that the phenylene and phenyl groups bind to each other directly or through a spacer having an atomic chain length of two or less; n stands for 1 or 2; ring A stands for a benzene ring having an optional substituent in addition to R.sup.2 ; Y stands for a bond, --O--, --S(O).sub.m -- (wherein m stands for 0, 1 or 2), or --N(R.sup.4)-- (wherein R.sup.4 stands for H or an optionally substituted alkyl group).

    摘要翻译： 本发明涉及用于糖尿病性肾病或肾小球肾炎的预防或治疗药物，其包含作为活性成分的由通式（I）表示的化合物或其盐，其中R1代表H或任选取代的烃残基 ; R2代表任选酯化的羧基; R3代表实际上或潜在能够形成阴离子的组; X表示亚苯基和苯基直接或通过原子链长度为2或更小的间隔物彼此结合; n代表1或2; 环A代表除R2之外具有任选取代基的苯环; Y代表键，-O - ， - S（O）m-（其中m代表0,1或2）或-N（R 4） - （其中R 4表示H或任选取代的烷基）。

    Prophylactic or therapeutic drug for renal diseases
    6.
    发明授权
    Prophylactic or therapeutic drug for renal diseases 失效
    肾病预防或治疗药物

    公开(公告)号：US06686383B2

    公开(公告)日：2004-02-03

    申请号：US10227537

    申请日：2002-08-26

    申请人： Kohei Nishikawa ,  Yumiko Shibouta ,  Keiji Kubo

    发明人： Kohei Nishikawa ,  Yumiko Shibouta ,  Keiji Kubo

    IPC分类号： A61K3141

    CPC分类号： A61K31/4184 ,  A61K31/415 ,  A61K31/4245 ,  Y02A50/395

    摘要： This invention relates to methods for the prophylaxis or treatment of diabetic nephropathy comprising, administering as an active ingredient, a compound, or salt thereof, of formula (I) wherein R1 stands for H or lower alkyl; R2 stands for an optionally esterified carboxyl group; R3 stands for a group actually or potentially capable of forming an anion; X shows that the phenylene and phenyl groups bind to each other directly or through a spacer having an atomic chain length of two or less; n stands for 1 or 2; ring A stands for a benzene ring; Y stands for a bond, —O—, —S(O)m— wherein m stands for 0, 1 or 2, or —N(R4)— wherein R4 stands for H or an optionally substituted alkyl group).

    摘要翻译： 本发明涉及预防或治疗糖尿病性肾病的方法，包括给予其中R 1代表H或低级烷基的式（Ⅰ）化合物或其盐作为活性成分; R 2代表任选酯化的羧基; R 3代表实际上或潜在地能够形成阴离子的基团; X表示亚苯基和苯基直接或通过原子链长度为2或更小的间隔物彼此结合; n代表1或2; 环A代表苯环; Y代表键，-O - ， - S（O）m-，其中m代表0,1或2或-N（R 4） - ，其中R 4代表H或任选取代的烷基 组）。

    Prophylactic or therapeutic drug for renal diseases
    7.
    发明授权
    Prophylactic or therapeutic drug for renal diseases 失效
    肾病预防或治疗药物

    公开(公告)号：US06469037B2

    公开(公告)日：2002-10-22

    申请号：US09977476

    申请日：2001-10-16

    申请人： Kohei Nishikawa ,  Yumiko Shibouta ,  Keiji Kubo

    发明人： Kohei Nishikawa ,  Yumiko Shibouta ,  Keiji Kubo

    IPC分类号： A61K3141

    CPC分类号： A61K31/4184 ,  A61K31/415 ,  A61K31/4245 ,  Y02A50/395

    摘要： This invention relates to methods for lowering urinary total protein comprising, administering as an active ingredient, a compound or salt thereof represented by general formula (I) wherein R1 stands for H or alkyl; R2 stands for an optionally esterified carboxyl group; R3 stands for a group actually or potentially capable of forming an anion; X shows that the phenylene and phenyl groups bind to each other directly or through a spacer having an atomic chain length of two or less; n stands for 1 or 2; ring A stands for a benzene ring having an optional substituent in addition to R2; Y stands for a bond, —O—, —S(O)m— wherein m stands for 0, 1 or 2, or —N(R4)— wherein R4 stands for H or an optionally substituted alkyl group.

    摘要翻译： 本发明涉及降低尿总蛋白的方法，其包括给予作为活性成分的由通式（I）表示的化合物或其盐，其中R1代表H或烷基; R2代表任选酯化的羧基; R3代表实际上或潜在能够形成阴离子的组; X表示亚苯基和苯基直接或通过原子链长度为2或更小的间隔物彼此结合; n代表1或2; 环A代表除R2之外具有任选取代基的苯环; Y代表键，-O - ， - S（O）m-，其中m代表0,1或2或-N（R4） - ，其中R4代表H或任选取代的烷基。

    Tricyclic nitrogen ring compounds, their production and use
    8.
    发明授权
    Tricyclic nitrogen ring compounds, their production and use 失效
    三环氮环化合物，其生产和使用

    公开(公告)号：US5958942A

    公开(公告)日：1999-09-28

    申请号：US783101

    申请日：1997-01-14

    申请人： Muneo Takatani ,  Yumiko Shibouta ,  Kiminori Tomimatsu ,  Tetsuji Kawamoto

    发明人： Muneo Takatani ,  Yumiko Shibouta ,  Kiminori Tomimatsu ,  Tetsuji Kawamoto

    IPC分类号： C07D471/16 ,  C07D471/04 ,  A61K31/44 ,  C07D401/06

    CPC分类号： C07D471/16

    摘要： Tricyclic compound of the formula: ##STR1## wherein ring A is a nitrogen-containing heterocyclic ring, having two nitrogen atoms as the hetero-atoms, which is optionally substituted with oxo or thioxo; ring Q may optionally be substituted; Y is an optionally substituted hydrocarbon group, an optionally substituted hydroxyl group or an optionally substituted mecapto group, excluding for methyl group as Y; R.sup.1 is a hydrogen atom, a halogen atom, an optionally substituted hydrocarbon group or an acyl group, or a salt thereof, having excellent PDGF-inhibiting activities, antihypertensive activities, activities of ameliorating renal diseases and activities of lowering lipid level.

    摘要翻译： 下式的三环化合物：其中环A是含氮杂环，具有两个氮原子作为杂原子，其任选被氧代或硫代基取代; 环Q可任选被取代; Y是任选取代的烃基，任选取代的羟基或任选取代的mecapto基团，不包括甲基作为Y; R1是具有优异的PDGF抑制活性，抗高血压活性，改善肾脏疾病的活性和降低脂质水平的活性的氢原子，卤素原子，任选取代的烃基或酰基或其盐。

    Fused imidazopyridine derivatives as antihyperlipidemic agents
    10.
    发明授权
    Fused imidazopyridine derivatives as antihyperlipidemic agents 失效
    融合的咪唑并吡啶衍生物作为抗高血脂药物

    公开(公告)号：US06235731B1

    公开(公告)日：2001-05-22

    申请号：US09155889

    申请日：1998-10-08

    申请人： Yumiko Shibouta ,  Yasuo Sugiyama ,  Tetsuji Kawamoto ,  Muneo Takatani

    发明人： Yumiko Shibouta ,  Yasuo Sugiyama ,  Tetsuji Kawamoto ,  Muneo Takatani

    IPC分类号： A61K31549

    CPC分类号： C07D513/16

    摘要： A novel compound of the formula: wherein ring Q is an optionally substituted pyridine ring; One of R0, R1 and R2 is —Y0—Z0, and the other tow groups are a hydrogen, a halogen, an optionally substituted hydroxy group, a hydrocarbon group that may be an optionally substituted hydrocarbon group or an acyl group; Y0 is a bond or an optionally substituted bivalent hydrocarbon group; Z0 is a basic group which may be bonded via oxygen, nitrogen, —CO—, —CS—, —SO2N(R3)— (where R3 is hydrogen or an optionally substituted hydrocarbon group), or S(O)n (wherein n is to 0, 1 or 2); ......... is a single bond or a double bond, or a salt thereof, which has an excellent LDL receptor up-regulating, blood-lipids lowering, blood-sugar lowering and diabetic complication-ameliorating activity.

    摘要翻译： 一种下式的新化合物：其中环Q是任选取代的吡啶环; R 0，R 1和R 2之一是-YO-Z 0，其它的三个基团是氢，卤素，任选取代的羟基，烃 可以是任意取代的烃基或酰基的基团; Y 0是一个键或任意取代的二价烃基; Z 0是可以通过氧，氮，-CO-，-CS-，-SO 2 N键合的碱性基团 （R 3） - （其中R 3是氢或任选取代的烃基）或S（O）n（其中n是0,1或2）; .........是单键或 双键或其盐，其具有优异的LDL受体上调，血脂降低，血糖降低和糖尿病并发症改善活性。