发明授权
- 专利标题： Mono- or polyenic carboxylic acid derivatives
- 专利标题（中）： 单或多元羧酸衍生物
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申请号： US09401732申请日： 1999-09-23
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公开(公告)号： US06291508B1公开(公告)日： 2001-09-18
- 发明人: Shigeki Hibi , Kouichi Kikuchi , Hiroyuki Yoshimura , Mitsuo Nagai , Katsuya Tagami , Shinya Abe , Ieharu Hishinuma , Junichi Nagakawa , Norimasa Miyamoto , Takayuki Hida , Aichi Ogasawara , Seiko Higashi , Kenji Tai , Takashi Yamanaka , Makoto Asada
- 申请人： Shigeki Hibi , Kouichi Kikuchi , Hiroyuki Yoshimura , Mitsuo Nagai , Katsuya Tagami , Shinya Abe , Ieharu Hishinuma , Junichi Nagakawa , Norimasa Miyamoto , Takayuki Hida , Aichi Ogasawara , Seiko Higashi , Kenji Tai , Takashi Yamanaka , Makoto Asada
- 优先权： JP6-267287 19941031; JP7-166120 19950630
- 主分类号： C07D20918
- IPC分类号： C07D20918
摘要：
Mono- or polyenic carboxylic acid derived compounds of the formula (1-I) or a physiologically acceptable salt thereof: Z—(CR3═CR2)n—COOR1 (1-I) wherein R1 is hydrogen or a carboxyl-protecting group; R2 and R3 are each independently hydrogen, halogen, linear lower alkyl, branched lower alkyl linear lower alkoxy, branched lower alkoxy or aryl, m is 1 to 3 and Z is a group or their salts have the potent ability to bind to retinoic acid receptors thus useful in treating psoriasis and rheumatoid arthritis.