发明授权
US06660714B1 &agr;-O-linked glycoconjugates, methods of preparation and uses thereof
失效
α-O-连接的糖缀合物，其制备方法和用途
- 专利标题： &agr;-O-linked glycoconjugates, methods of preparation and uses thereof
- 专利标题（中）： α-O-连接的糖缀合物，其制备方法和用途
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申请号： US09083776申请日： 1998-03-25
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公开(公告)号： US06660714B1公开(公告)日： 2003-12-09
- 发明人: Samuel J. Danishefsky , Dalibor Sames , Samuel Hintermann , Xiao-Tao Chen , Jacob B. Schwartz , Peter Glunz , Govindaswami Ragupathi , Philip O. Livingston , Scott Kuduk , Lawrence Williams
- 申请人： Samuel J. Danishefsky , Dalibor Sames , Samuel Hintermann , Xiao-Tao Chen , Jacob B. Schwartz , Peter Glunz , Govindaswami Ragupathi , Philip O. Livingston , Scott Kuduk , Lawrence Williams
- 主分类号： A01N3718
- IPC分类号： A01N3718
摘要：
The present invention provides novel &agr;-O-linked glycoconjugates such as &agr;-O-linked glycopeptides, as well convergent methods for synthesis thereof. The general preparative approach is exemplified by the synthesis of the mucin motif commonly found on epithelial tumor cell surfaces. The present invention further provides compositions and methods of treating cancer using the &agr;-O-linked glycoconjugates.
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