发明授权
- 专利标题： Inhibitors of proteasomal activity for stimulating bone growth
- 专利标题（中）： 用于刺激骨生长的蛋白酶体活性抑制剂
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申请号： US09695807申请日： 2000-10-23
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公开(公告)号： US06838436B1公开(公告)日： 2005-01-04
- 发明人: Gregory R. Mundy , I. Ross Garrett , Jorge Gianny Rossini
- 申请人： Gregory R. Mundy , I. Ross Garrett , Jorge Gianny Rossini
- 申请人地址： US TX San Antonio
- 专利权人： Osteoscreen Inc.
- 当前专利权人： Osteoscreen Inc.
- 当前专利权人地址： US TX San Antonio
- 代理机构： Morrison & Foerster LLP
- 主分类号： A61K8/64
- IPC分类号： A61K8/64 ; A61K31/00 ; A61K31/351 ; A61K31/365 ; A61K31/4015 ; A61K31/522 ; A61K38/05 ; A61K38/06 ; A61K38/07 ; A61K45/06 ; A61Q7/00 ; A61K38/00
摘要：
The present invention relates to compounds that inhibit the activity of the proteasome or the productions of proteasomal proteins and promote bone formation and are thus useful in treating osteoporosis, bone fracture or deficiency, primary or secondary hyperparathyroidism, periodontal disease or defect, metastatic bone disease, osteolytic bone disease, post-plastic surgery, post-prosthetic joint surgey, and post-dental implantation, in subject where this is desirable.
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