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公开(公告)号：US06838436B1
公开(公告)日：2005-01-04
申请号：US09695807
申请日：2000-10-23
IPC分类号： A61K8/64 , A61K31/00 , A61K31/351 , A61K31/365 , A61K31/4015 , A61K31/522 , A61K38/05 , A61K38/06 , A61K38/07 , A61K45/06 , A61Q7/00 , A61K38/00
CPC分类号： A61K8/64 , A61K31/00 , A61K31/351 , A61K31/365 , A61K31/4015 , A61K31/522 , A61K31/7042 , A61K38/05 , A61K38/06 , A61K38/07 , A61K45/06 , A61Q7/00 , A61K2300/00
摘要： The present invention relates to compounds that inhibit the activity of the proteasome or the productions of proteasomal proteins and promote bone formation and are thus useful in treating osteoporosis, bone fracture or deficiency, primary or secondary hyperparathyroidism, periodontal disease or defect, metastatic bone disease, osteolytic bone disease, post-plastic surgery, post-prosthetic joint surgey, and post-dental implantation, in subject where this is desirable.
摘要翻译： 本发明涉及抑制蛋白酶体活性或蛋白酶体蛋白的产生并促进骨形成的化合物，因此可用于治疗骨质疏松症，骨折或缺陷，原发性或继发性甲状旁腺功能亢进，牙周病或缺陷，转移性骨病， 溶骨性骨病，整形后手术，假体后关节活动和牙周后植入术，这是可取的。
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公开(公告)号：US06656904B2
公开(公告)日：2003-12-02
申请号：US10050633
申请日：2002-01-15
IPC分类号： A01N3718
CPC分类号： A61K31/7042 , A61K8/64 , A61K31/00 , A61K31/351 , A61K31/365 , A61K31/4015 , A61K31/522 , A61K38/05 , A61K38/06 , A61K38/07 , A61K45/06 , A61Q7/00 , Y10S514/88 , A61K2300/00
摘要： The present invention relates to compounds that inhibit the activity of the proteasome or the production of proteasomal proteins and promote hair growth and the production of hair follicles and are thus useful in stimulating hair growth, including hair density, in subject where this is desirable.
摘要翻译： 本发明涉及抑制蛋白酶体活性或蛋白酶体蛋白的产生并促进毛发生长和毛囊生成的化合物，因此可用于在需要的受试者中刺激头发生长（包括毛发密度）。
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公开(公告)号：US06884769B1
公开(公告)日：2005-04-26
申请号：US09558973
申请日：2000-04-25
IPC分类号： A61K8/64 , A61K31/00 , A61K31/351 , A61K31/365 , A61K31/4015 , A61K31/522 , A61K38/05 , A61K38/06 , A61K38/07 , A61K45/06 , A61Q7/00 , A61K38/00
CPC分类号： A61K31/7042 , A61K8/64 , A61K31/00 , A61K31/351 , A61K31/365 , A61K31/4015 , A61K31/522 , A61K38/05 , A61K38/06 , A61K38/07 , A61K45/06 , A61Q7/00 , Y10S514/88 , A61K2300/00
摘要： Compounds that inhibit the activity of NF-κB or inhibit the activity of the proteasome or both promote bone formation and hair growth and are thus useful in treating osteoporosis, bone fracture or deficiency, primary or secondary hyperparathyrdidism, periodontal disease or defect, metastatic bone disease, osteolytic bone disease, post-plastic surgery, post-prosthetic joint surgery, and post-dental implantation; they also stimulate the production of hair follicles and are thus useful in stimulating hair growth, including hair density, in subject where this is desirable.
摘要翻译： 抑制NF-κB活性或抑制蛋白酶体活性的化合物或促进骨形成和毛发生长，因此可用于治疗骨质疏松症，骨折或缺陷，原发性或继发性过度帕金森氏症，牙周病或缺陷，转移性骨病 ，溶骨性骨病，整形外科，后修复关节手术和牙后植入术; 它们也刺激毛囊的产生，因此可用于刺激毛发生长，包括毛发密度，在这是理想的对象。
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公开(公告)号：US06838252B2
公开(公告)日：2005-01-04
申请号：US10052832
申请日：2002-01-15
IPC分类号： A61K8/64 , A61K31/00 , A61K31/351 , A61K31/365 , A61K31/4015 , A61K31/522 , A61K38/05 , A61K38/06 , A61K38/07 , A61K45/06 , A61Q7/00 , C12Q1/37
CPC分类号： A61K31/7042 , A61K8/64 , A61K31/00 , A61K31/351 , A61K31/365 , A61K31/4015 , A61K31/522 , A61K38/05 , A61K38/06 , A61K38/07 , A61K45/06 , A61Q7/00 , Y10S514/88 , A61K2300/00
摘要： The present invention relates to compounds that inhibit the activity of the proteasome or the production of proteasomal proteins and promote the production of hair follicles and are thus useful in stimulating hair growth, including hair density, in subject where this is desirable.
摘要翻译： 本发明涉及抑制蛋白酶体活性或产生蛋白酶体蛋白质并促进毛囊生成的化合物，因此可用于刺激毛发生长（包括毛发密度），在此是理想的对象。
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公开(公告)号：US07175994B2
公开(公告)日：2007-02-13
申请号：US10894189
申请日：2004-07-19
IPC分类号： C12Q1/37
CPC分类号： A61K31/7042 , A61K8/64 , A61K31/00 , A61K31/351 , A61K31/365 , A61K31/4015 , A61K31/522 , A61K38/05 , A61K38/06 , A61K38/07 , A61K45/06 , A61Q7/00 , Y10S514/88 , A61K2300/00
摘要： Compounds that inhibit the activity of the proteasome or the production of proteasomal proteins promote hair growth by stimulating the production of hair follicles, and are thus useful in stimulating hair growth, including hair density, in subject where this is desirable.
摘要翻译： 抑制蛋白酶体活性或生成蛋白酶体蛋白质的化合物通过刺激毛囊的产生来促进毛发生长，并且因此可用于刺激毛发生长，包括头发密度，在需要的对象中。
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公开(公告)号：US07223554B2
公开(公告)日：2007-05-29
申请号：US11026691
申请日：2004-12-30
IPC分类号： C12Q1/37
CPC分类号： A61K31/7042 , A61K8/64 , A61K31/00 , A61K31/351 , A61K31/365 , A61K31/4015 , A61K31/522 , A61K38/05 , A61K38/06 , A61K38/07 , A61K45/06 , A61Q7/00 , Y10S514/88 , A61K2300/00
摘要： Compounds that inhibit the activity of the proteasome or the production of proteasomal proteins promote hair growth by stimulating the production of hair follicles, and are thus useful in stimulating hair growth, including hair density, in subject where this is desirable.
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公开(公告)号：US06410512B1
公开(公告)日：2002-06-25
申请号：US09361775
申请日：1999-07-27
申请人： Gregory R. Mundy , I. Ross Garrett , G. Rossini
发明人： Gregory R. Mundy , I. Ross Garrett , G. Rossini
IPC分类号： A61K3800
CPC分类号： A61K45/06 , A61K8/64 , A61K31/00 , A61K31/165 , A61K31/166 , A61K31/27 , A61K31/351 , A61K31/366 , A61K31/40 , A61K31/4015 , A61K31/435 , A61K31/66 , A61K38/05 , A61K38/06 , A61K2800/91 , A61Q7/00 , G01N33/6872 , G01N2500/00 , Y10S514/88 , A61K2300/00
摘要： Compounds that inhibit the activity of NF-&kgr;B or inhibit the activity of the proteasome or both promote hair growth and stimulate the production of hair follicles and are thus useful in stimulating hair growth, including hair density, in subject where this is desirable.
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8.发明授权公开(公告)号：US06462019B1
公开(公告)日：2002-10-08
申请号：US09113947
申请日：1998-07-10
申请人： Gregory R. Mundy , I. Ross Garrett , G. Rossini
发明人： Gregory R. Mundy , I. Ross Garrett , G. Rossini
IPC分类号： A61K3800
CPC分类号： A61K45/06 , A61K8/64 , A61K31/00 , A61K31/165 , A61K31/166 , A61K31/27 , A61K31/351 , A61K31/366 , A61K31/40 , A61K31/4015 , A61K31/435 , A61K31/66 , A61K38/05 , A61K38/06 , A61K2800/91 , A61Q7/00 , G01N33/6872 , G01N2500/00 , Y10S514/88 , A61K2300/00
摘要： Compounds that inhibit the activity of NF-&kgr;B or inhibit the activity of the proteasome or both promote bone formation and are thus useful in treating osteoporosis, bone fracture or deficiency, primary or secondary hyperparathyroidism, periodontal disease or defect, metastatic bone disease, osteolytic bone disease, post-plastic surgery, post-prosthetic joint surgery, and post-dental implantation.
摘要翻译： 抑制NF-κB活性或抑制蛋白酶体活性或两者促进骨形成的化合物有助于治疗骨质疏松症，骨折或缺陷，原发性或继发性甲状旁腺功能亢进，牙周病或缺损，转移性骨病，溶骨性骨 疾病，后整形手术，假体后关节手术和牙植入后。
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公开(公告)号：US06902721B1
公开(公告)日：2005-06-07
申请号：US09421545
申请日：1999-10-20
IPC分类号： A61K8/64 , A61K31/00 , A61K31/351 , A61K31/365 , A61K31/4015 , A61K31/522 , A61K38/05 , A61K38/06 , A61K38/07 , A61K45/06 , A61Q7/00 , A61K7/16
CPC分类号： A61K31/7042 , A61K8/64 , A61K31/00 , A61K31/351 , A61K31/365 , A61K31/4015 , A61K31/522 , A61K38/05 , A61K38/06 , A61K38/07 , A61K45/06 , A61Q7/00 , Y10S514/88 , A61K2300/00
摘要： The present invention relates to compounds that inhibit the activity of the proteasome or the production of proteasomal proteins and promote bone formation and are thus useful in treating osteoporosis, bone fracture or deficiency, primary or secondary hyperparathyroidism, periodontal disease or defect, metastatic bone disease, osteolytic bone disease, post-plastic surgery, post-prosthetic joint surgery, and post-dental implantation, in subject where this is desirable.
摘要翻译： 本发明涉及抑制蛋白酶体活性或蛋白酶体蛋白生成并促进骨形成的化合物，因此可用于治疗骨质疏松症，骨折或缺陷，原发性或继发性甲状旁腺功能亢进，牙周病或缺陷，转移性骨病， 溶骨性骨病，后整形手术，假体后关节外科手术和牙后植入术，在此是可取的。
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公开(公告)号：US06958220B2
公开(公告)日：2005-10-25
申请号：US10050425
申请日：2002-01-15
IPC分类号： A61K45/00 , A61K31/00 , A61K31/351 , A61K31/40 , A61K31/4015 , A61K31/522 , A61K31/566 , A61K31/663 , A61K38/00 , A61K38/05 , A61K38/06 , A61K38/27 , A61K45/06 , A61P1/02 , A61P17/14 , A61P19/02 , A61P19/08 , A61P19/10 , C12Q1/37
CPC分类号： A61K45/06 , A61K8/64 , A61K31/00 , A61K31/165 , A61K31/166 , A61K31/27 , A61K31/351 , A61K31/366 , A61K31/40 , A61K31/4015 , A61K31/435 , A61K31/66 , A61K38/05 , A61K38/06 , A61K2800/91 , A61Q7/00 , G01N33/6872 , G01N2500/00 , Y10S514/88 , A61K2300/00
摘要： This inventions relates to compounds that inhibit the activity of the proteasome and both promotes hair growth and stimulates the production of hair follicles. The compounds provided herein are thus useful in stimulating hair growth, including hair density, in subject where this is desirable.
摘要翻译： 本发明涉及抑制蛋白酶体活性并且促进毛发生长并刺激毛囊生成的化合物。 因此，本文提供的化合物可用于在需要的受试者中刺激包括毛发密度的毛发生长。
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