发明授权
- 专利标题： Heterocycles useful in the treatment of benign prostatic hyperplasia
- 专利标题（中）： 用于治疗良性前列腺增生的杂环
-
申请号： US09994153申请日： 2001-11-26
-
公开(公告)号： US06841682B2公开(公告)日： 2005-01-11
- 发明人: Richard H. Hutchings , Haripada Khatuya , Gee-Hong Kuo , Xiaobing Li , William V. Murray , Catherine Prouty , Frank Villani , Nelson C. F. Yim , Cynthia Maryanoff
- 申请人： Richard H. Hutchings , Haripada Khatuya , Gee-Hong Kuo , Xiaobing Li , William V. Murray , Catherine Prouty , Frank Villani , Nelson C. F. Yim , Cynthia Maryanoff
- 申请人地址： BE
- 专利权人： Janseen Pharmaceutica N.V.
- 当前专利权人： Janseen Pharmaceutica N.V.
- 当前专利权人地址： BE
- 代理商 Laura Donnelly
- 主分类号： C07D295/08
- IPC分类号： C07D295/08 ; A61K31/495 ; A61K31/496 ; A61K31/506 ; A61P13/08 ; A61P43/00 ; C07D211/76 ; C07D213/38 ; C07D261/08 ; C07D263/32 ; C07D263/34 ; C07D277/20 ; C07D277/28 ; C07D277/56 ; C07D295/10 ; C07D295/108 ; C07D295/12 ; C07D295/13 ; C07D333/20 ; C07D333/22 ; C07D333/28 ; C07D401/06 ; C07D409/06 ; C07D413/06 ; C07D417/06
摘要：
This invention relates a to a series of heterocyclic substituted piperazines of Formula I pharmaceutical compositions containing them and intermediates used in their manufacture. The compounds of the invention selectively inhibit binding to the α-1a adrenergic receptor, a receptor which has been implicated in benign prostatic hyperplasia. As such the compounds are potentially useful in the treatment of this disease.
公开/授权文献
信息查询
