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1.
公开(公告)号:US06841682B2
公开(公告)日:2005-01-11
申请号:US09994153
申请日:2001-11-26
申请人: Richard H. Hutchings , Haripada Khatuya , Gee-Hong Kuo , Xiaobing Li , William V. Murray , Catherine Prouty , Frank Villani , Nelson C. F. Yim , Cynthia Maryanoff
发明人: Richard H. Hutchings , Haripada Khatuya , Gee-Hong Kuo , Xiaobing Li , William V. Murray , Catherine Prouty , Frank Villani , Nelson C. F. Yim , Cynthia Maryanoff
IPC分类号: C07D295/08 , A61K31/495 , A61K31/496 , A61K31/506 , A61P13/08 , A61P43/00 , C07D211/76 , C07D213/38 , C07D261/08 , C07D263/32 , C07D263/34 , C07D277/20 , C07D277/28 , C07D277/56 , C07D295/10 , C07D295/108 , C07D295/12 , C07D295/13 , C07D333/20 , C07D333/22 , C07D333/28 , C07D401/06 , C07D409/06 , C07D413/06 , C07D417/06
CPC分类号: C07D263/34 , C07D211/76 , C07D213/38 , C07D261/08 , C07D263/32 , C07D277/28 , C07D277/56 , C07D295/108 , C07D295/13 , C07D333/20 , C07D333/22 , C07D333/28 , C07D401/06 , C07D409/06 , C07D413/06 , C07D417/06
摘要: This invention relates a to a series of heterocyclic substituted piperazines of Formula I pharmaceutical compositions containing them and intermediates used in their manufacture. The compounds of the invention selectively inhibit binding to the α-1a adrenergic receptor, a receptor which has been implicated in benign prostatic hyperplasia. As such the compounds are potentially useful in the treatment of this disease.
摘要翻译: 本发明涉及一系列含有它们的式Iph药物组合物的杂环取代的哌嗪和其制备中使用的中间体。 本发明的化合物选择性地抑制与α-1a肾上腺素能受体的结合,α受体是与良性前列腺增生有关的受体。 因此,这些化合物潜在地用于治疗这种疾病。
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2.
公开(公告)号:US06384035B1
公开(公告)日:2002-05-07
申请号:US09169571
申请日:1998-10-09
申请人: Richard H. Hutchings , Haripada Khatuya , Gee-Hong Kuo , Xiaobing Li , William V. Murray , Catherine Prouty , Frank Villani , Nelson C. F. Yim , Cynthia Maryanoff
发明人: Richard H. Hutchings , Haripada Khatuya , Gee-Hong Kuo , Xiaobing Li , William V. Murray , Catherine Prouty , Frank Villani , Nelson C. F. Yim , Cynthia Maryanoff
IPC分类号: A01N4300
CPC分类号: C07D263/34 , C07D211/76 , C07D213/38 , C07D261/08 , C07D263/32 , C07D277/28 , C07D277/56 , C07D295/108 , C07D295/13 , C07D333/20 , C07D333/22 , C07D333/28 , C07D401/06 , C07D409/06 , C07D413/06 , C07D417/06
摘要: This invention relates a to a series of heterocyclic substituted piperazines of Formula I pharmaceutical compositions containing them and intermediates used in their manufacture. The compounds of the invention selectively inhibit binding to the &agr;-1a adrenergic receptor, a receptor which has been implicated in benign prostatic hyperplasia. As such the compounds are potentially useful in the treatment of this disease.
摘要翻译: 本发明涉及一系列含有它们的式Iph药物组合物的杂环取代的哌嗪和其制备中使用的中间体。 本发明的化合物选择性地抑制与α-1a肾上腺素能受体的结合,α受体是与良性前列腺增生有关的受体。 因此,这些化合物潜在地用于治疗这种疾病。
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公开(公告)号:US20070004738A1
公开(公告)日:2007-01-04
申请号:US11517171
申请日:2006-09-07
申请人: Mary Beavers , J. Breitenbucher , Hui Cai , James Edwards , Cheryl Grice , Darin Gustin , Haripada Khatuya , Steven Meduna , Barbara Pio , Kevin Tays , Jianmei Wei
发明人: Mary Beavers , J. Breitenbucher , Hui Cai , James Edwards , Cheryl Grice , Darin Gustin , Haripada Khatuya , Steven Meduna , Barbara Pio , Kevin Tays , Jianmei Wei
IPC分类号: A61K31/498 , C07D487/02
CPC分类号: C07D231/12 , C07D471/04
摘要: Substituted pyrazoles, methods of manufacturing them, compositions containing them, and methods of using them to treat, for example, autoimmune diseases mediated by cathepsin S.
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公开(公告)号:US07772236B2
公开(公告)日:2010-08-10
申请号:US12220539
申请日:2008-07-24
申请人: Mary Pat Beavers , J. Guy Breitenbucher , Hui Cai , James P. Edwards , Cheryl A. Grice , Darin J. Gustin , Haripada Khatuya , Steven P. Meduna , Barbara A. Pio , Kevin L. Tays , Jianmei Wei
发明人: Mary Pat Beavers , J. Guy Breitenbucher , Hui Cai , James P. Edwards , Cheryl A. Grice , Darin J. Gustin , Haripada Khatuya , Steven P. Meduna , Barbara A. Pio , Kevin L. Tays , Jianmei Wei
IPC分类号: A61K31/497 , A61K31/24 , A61K31/505
CPC分类号: C07D231/12 , C07D471/04
摘要: Substituted pyrazoles, methods of manufacturing them, compositions containing them, and methods of using them to treat, for example, autoimmune diseases mediated by cathepsin S.
摘要翻译: 取代的吡唑,其制备方法,含有它们的组合物,以及使用它们来治疗例如由组织蛋白酶S介导的自身免疫疾病的方法。
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公开(公告)号:US07388011B2
公开(公告)日:2008-06-17
申请号:US11517171
申请日:2006-09-07
申请人: Mary Pat Beavers , J. Guy Breitenbucher , Hui Cai , James P. Edwards , Cheryl A. Grice , Darin J. Gustin , Haripada Khatuya , Steven P. Meduna , Barbara A. Pio , Kevin L. Tays , Jianmei Wei
发明人: Mary Pat Beavers , J. Guy Breitenbucher , Hui Cai , James P. Edwards , Cheryl A. Grice , Darin J. Gustin , Haripada Khatuya , Steven P. Meduna , Barbara A. Pio , Kevin L. Tays , Jianmei Wei
IPC分类号: A61K31/495 , C07D471/04
CPC分类号: C07D231/12 , C07D471/04
摘要: Substituted pyrazoles, methods of manufacturing them, compositions containing them, and methods of using them to treat, for example, autoimmune diseases mediated by cathepsin S.
摘要翻译: 取代的吡唑,其制备方法,含有它们的组合物,以及使用它们来治疗例如由组织蛋白酶S介导的自身免疫性疾病的方法。
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公开(公告)号:US07332494B2
公开(公告)日:2008-02-19
申请号:US10075673
申请日:2002-02-13
申请人: J. Guy Breitenbucher , Hui Cai , James P. Edwards , Cheryl A. Grice , Yin Gu , Darin J. Gustin , Lars Karlsson , Haripada Khatuya , Steven P. Meduna , Barbara A. Pio , Siquan Sun , Kevin L. Tays , Robin L. Thurmond , Jianmei Wei
发明人: J. Guy Breitenbucher , Hui Cai , James P. Edwards , Cheryl A. Grice , Yin Gu , Darin J. Gustin , Lars Karlsson , Haripada Khatuya , Steven P. Meduna , Barbara A. Pio , Siquan Sun , Kevin L. Tays , Robin L. Thurmond , Jianmei Wei
IPC分类号: A61K31/497 , A61K31/50 , A61K31/53 , A61K31/505
CPC分类号: C07D231/12 , C07D471/04
摘要: A method for treating an allergic condition, including an atopic allergic condition, using substituted pyrazoles.
摘要翻译: 一种使用取代的吡唑治疗过敏性疾病(包括特应性过敏症状)的方法。
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公开(公告)号:US20070004755A1
公开(公告)日:2007-01-04
申请号:US11517145
申请日:2006-09-07
申请人: Mary Beavers , J. Breitenbucher , Hui Cai , James Edwards , Cheryl Grice , Darin Gustin , Haripada Khatuya , Steven Meduna , Barbara Pio , Kevin Tays , Jianmei Wei
发明人: Mary Beavers , J. Breitenbucher , Hui Cai , James Edwards , Cheryl Grice , Darin Gustin , Haripada Khatuya , Steven Meduna , Barbara Pio , Kevin Tays , Jianmei Wei
IPC分类号: A61K31/496 , C07D403/02
CPC分类号: C07D231/12 , C07D471/04
摘要: Substituted pyrazoles, methods of manufacturing them, compositions containing them, and methods of using them to treat, for example, autoimmune diseases mediated by cathepsin S.
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8.Heterocyclic derivatives for treatment of hyperlipidemia and related diseases 审中-公开
标题翻译: 用于治疗高脂血症和相关疾病的杂环衍生物公开(公告)号:US20060009487A1
公开(公告)日:2006-01-12
申请号:US11149067
申请日:2005-06-09
IPC分类号: C07D215/12 , A61K31/47
CPC分类号: A61K31/47 , C07D207/34 , C07D215/12 , C07D215/54 , C07D231/40 , C07D401/12
摘要: The present invention provides compositions adapted to enhance reverse cholesterol transport in mammals. The compositions are suitable for oral delivery and useful in the treatment and/or prevention of hypercholesterolemia, atherosclerosis and associated cardiovascular diseases.
摘要翻译: 本发明提供适于增强哺乳动物逆向胆固醇转运的组合物。 所述组合物适用于口服递送,并且可用于治疗和/或预防高胆固醇血症,动脉粥样硬化和相关的心血管疾病。
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公开(公告)号:US20050245576A1
公开(公告)日:2005-11-03
申请号:US11174077
申请日:2005-06-30
申请人: Christopher Butler , Hui Cai , James Edwards , Cheryl Grice , Darin Gustin , Haripada Khatuya , Steven Meduna , Barbara Pio , Clark Sehon , Kevin Tays , Jianmei Wei
发明人: Christopher Butler , Hui Cai , James Edwards , Cheryl Grice , Darin Gustin , Haripada Khatuya , Steven Meduna , Barbara Pio , Clark Sehon , Kevin Tays , Jianmei Wei
IPC分类号: C07D401/14 , A61K31/275 , A61K31/4155 , A61K31/437 , A61K31/454 , A61K31/4545 , A61K31/495 , A61K31/517 , A61K31/5377 , A61K31/538 , A61K31/5383 , A61K31/549 , A61K31/55 , A61P11/06 , A61P29/00 , A61P37/06 , A61P43/00 , C07D413/14 , C07D471/04 , C07D471/14 , C07D519/00 , C07D43/02
CPC分类号: C07D413/14 , A61K31/275 , A61K31/4155 , A61K31/454 , A61K31/495 , A61K31/55 , C07D471/04 , C07D471/14
摘要: Substituted pyrazoles, methods of manufacturing them, compositions containing them, and methods of using them to treat, for example, autoimmune diseases mediated by cathepsin S are described.
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公开(公告)号:US07589202B2
公开(公告)日:2009-09-15
申请号:US11517062
申请日:2006-09-07
申请人: Mary Pat Beavers , J. Guy Breitenbucher , Hui Cai , James P. Edwards , Cheryl A. Grice , Darin J. Gustin , Haripada Khatuya , Steven P. Meduna , Barbara A. Pio , Kevin L. Tays , Jianmei Wei
发明人: Mary Pat Beavers , J. Guy Breitenbucher , Hui Cai , James P. Edwards , Cheryl A. Grice , Darin J. Gustin , Haripada Khatuya , Steven P. Meduna , Barbara A. Pio , Kevin L. Tays , Jianmei Wei
IPC分类号: C07D403/06
CPC分类号: C07D231/12 , C07D471/04
摘要: Substituted pyrazoles, methods of manufacturing them, compositions containing them, and methods of using them to treat, for example, autoimmune diseases mediated by cathepsin S.
摘要翻译: 取代的吡唑,其制备方法,含有它们的组合物,以及使用它们来治疗例如由组织蛋白酶S介导的自身免疫性疾病的方法。
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