发明授权
US06867018B1 Alzheimer's disease secretase, APP substrates therefor, and uses thereof
失效
阿尔茨海默病分泌酶，APP底物及其用途
- 专利标题： Alzheimer's disease secretase, APP substrates therefor, and uses thereof
- 专利标题（中）： 阿尔茨海默病分泌酶，APP底物及其用途
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申请号： US09548365申请日： 2000-04-12
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公开(公告)号： US06867018B1公开(公告)日： 2005-03-15
- 发明人: Mark E. Gurney , Michael J. Bienkowski , Robert L. Heinrikson , Luis A. Parodi , Riqiang Yan
- 申请人： Mark E. Gurney , Michael J. Bienkowski , Robert L. Heinrikson , Luis A. Parodi , Riqiang Yan
- 申请人地址： US MI Kalamazoo
- 专利权人： Pharmacia & Upjohn Company
- 当前专利权人： Pharmacia & Upjohn Company
- 当前专利权人地址： US MI Kalamazoo
- 代理机构： Pharmacia & Upjohn Company
- 代理商 Thomas A. Wootton
- 主分类号： C07K14/47
- IPC分类号： C07K14/47 ; C12N1/21 ; C12N5/02 ; C12N5/08 ; C12N9/64 ; C12N15/12 ; C12N15/57 ; C12Q1/37 ; C12P21/06 ; C07H21/04 ; C12N1/20 ; C12N15/00
摘要：
The present invention provides the enzyme and enzymatic procedures for cleaving the β secretase cleavage site of the APP protein and associated nucleic acids, peptides, vectors, cells and cell isolates and assays. The invention further provides a modified APP protein and associated nucleic acids, peptides, vectors, cells, and cell isolates, and assays that are particularly useful for identifying candidate therapeutics for treatment or prevention of Alzheimer's disease.
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