发明授权
US06870032B1 Assay for the diagnosis of flaviviral infection using antibodies with high affinity for NS1 protein of flavivirus in hexameric form
有权
使用六聚体形式的黄病毒NS1蛋白具有高亲和力的抗体来测定黄病毒感染的检测
- 专利标题： Assay for the diagnosis of flaviviral infection using antibodies with high affinity for NS1 protein of flavivirus in hexameric form
- 专利标题（中）： 使用六聚体形式的黄病毒NS1蛋白具有高亲和力的抗体来测定黄病毒感染的检测
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申请号： US09980839申请日： 2000-06-09
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公开(公告)号： US06870032B1公开(公告)日： 2005-03-22
- 发明人: Marie Flamand , Françoise Megret , Sophie Alcon , Antoine Talarmin , Philippe Despres , Vincent Deubel
- 申请人： Marie Flamand , Françoise Megret , Sophie Alcon , Antoine Talarmin , Philippe Despres , Vincent Deubel
- 申请人地址： FR Paris
- 专利权人： Institut Pasteur
- 当前专利权人： Institut Pasteur
- 当前专利权人地址： FR Paris
- 代理机构： Finnegan, Henderson, Farabow, Garrett & Dunner, LLP
- 优先权： FR9907290 19990609; FR9907361 19990610
- 国际申请： PCTFR00/01620 WO 20000609
- 国际公布： WO0075665 WO 20001214
- 主分类号： A61K39/00
- IPC分类号： A61K39/00 ; A61K39/12 ; A61K39/395 ; A61K48/00 ; A61P31/14 ; C07K14/18 ; C07K16/10 ; C12N15/09 ; C12P21/02 ; G01N33/543 ; G01N33/569 ; G01N33/577 ; C07K16/00
摘要：
The invention concerns a method for early detection of a flavivirus-induced infection, comprising the detection of the flavivirus non-structural glycoprotein NS1 in a biological sample during the clinical phase of the infection, by an immunological method using at least two identical or different antibodies, the first antibody consisting of polyclonal or monoclonal antibodies pre-selected for their high affinity for said NS1 protein hexameric in shape.
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