发明授权
- 专利标题: Certain 1,3-disubstituted isoquinoline derivatives
- 专利标题(中): 某些1,3-二取代异喹啉衍生物
-
申请号: US10796673申请日: 2004-03-10
-
公开(公告)号: US06875761B2公开(公告)日: 2005-04-05
- 发明人: Kohshi Ueno , Atsushi Sasaki , Koki Kawano , Tadashi Okabe , Noritaka Kitazawa , Keiko Takahashi , Noboru Yamamoto , Yuichi Suzuki , Manabu Matsunaga , Atsuhiko Kubota
- 申请人: Kohshi Ueno , Atsushi Sasaki , Koki Kawano , Tadashi Okabe , Noritaka Kitazawa , Keiko Takahashi , Noboru Yamamoto , Yuichi Suzuki , Manabu Matsunaga , Atsuhiko Kubota
- 申请人地址: JP Tokyo
- 专利权人: Eisai Co., Ltd.
- 当前专利权人: Eisai Co., Ltd.
- 当前专利权人地址: JP Tokyo
- 代理机构: Birch, Stewart, Kolasch & Birch, LLP
- 优先权: JP9-284290 19971002
- 主分类号: C07D217/22
- IPC分类号: C07D217/22 ; C07D217/24 ; C07D401/04 ; C07D401/06 ; C07D401/10 ; C07D401/12 ; C07D405/04 ; C07D405/10 ; C07D409/04 ; C07D409/14 ; C07D413/10 ; C07D417/04 ; C07D417/12 ; C07D471/04 ; C07D491/04 ; C07D491/10 ; C07D495/04 ; A61K31/33 ; A61K31/47 ; A61K31/495 ; C07D217/00 ; C07D241/04
摘要:
Condensed pyridine compounds represented by formula (I): wherein: R1 and R3 are, independently, hydrogen, lower alkyl, or lower alkoxy; R2 represent an amino substituent; ring A is a benzene ring, pyridine ring, thiophene ring, or furan ring; and B represents a substituent containing a ring structure. Also, pharmaceutically acceptable salt and hydrates thereof. These compounds are clinically useful medicaments having serotonin antagonism, and in particular, for treating, ameliorating, or preventing spastic paralysis. They are also useful as central muscle relaxants for ameliorating myotonia.
公开/授权文献
- US20040204421A1 Certain 1,3-disubstituted isoquinoline derivatives 公开/授权日:2004-10-14
信息查询