Invention Grant
- Patent Title: Certain 1,3-disubstituted isoquinoline derivatives
- Patent Title (中): 某些1,3-二取代异喹啉衍生物
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Application No.: US10796673Application Date: 2004-03-10
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Publication No.: US06875761B2Publication Date: 2005-04-05
- Inventor: Kohshi Ueno , Atsushi Sasaki , Koki Kawano , Tadashi Okabe , Noritaka Kitazawa , Keiko Takahashi , Noboru Yamamoto , Yuichi Suzuki , Manabu Matsunaga , Atsuhiko Kubota
- Applicant: Kohshi Ueno , Atsushi Sasaki , Koki Kawano , Tadashi Okabe , Noritaka Kitazawa , Keiko Takahashi , Noboru Yamamoto , Yuichi Suzuki , Manabu Matsunaga , Atsuhiko Kubota
- Applicant Address: JP Tokyo
- Assignee: Eisai Co., Ltd.
- Current Assignee: Eisai Co., Ltd.
- Current Assignee Address: JP Tokyo
- Agency: Birch, Stewart, Kolasch & Birch, LLP
- Priority: JP9-284290 19971002
- Main IPC: C07D217/22
- IPC: C07D217/22 ; C07D217/24 ; C07D401/04 ; C07D401/06 ; C07D401/10 ; C07D401/12 ; C07D405/04 ; C07D405/10 ; C07D409/04 ; C07D409/14 ; C07D413/10 ; C07D417/04 ; C07D417/12 ; C07D471/04 ; C07D491/04 ; C07D491/10 ; C07D495/04 ; A61K31/33 ; A61K31/47 ; A61K31/495 ; C07D217/00 ; C07D241/04

Abstract:
Condensed pyridine compounds represented by formula (I): wherein: R1 and R3 are, independently, hydrogen, lower alkyl, or lower alkoxy; R2 represent an amino substituent; ring A is a benzene ring, pyridine ring, thiophene ring, or furan ring; and B represents a substituent containing a ring structure. Also, pharmaceutically acceptable salt and hydrates thereof. These compounds are clinically useful medicaments having serotonin antagonism, and in particular, for treating, ameliorating, or preventing spastic paralysis. They are also useful as central muscle relaxants for ameliorating myotonia.
Public/Granted literature
- US20040204421A1 Certain 1,3-disubstituted isoquinoline derivatives Public/Granted day:2004-10-14
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