A method and apparatus for optimizing distributed multiplexed bus interconnects are described. The multiplexed bus interconnect contains one or more multiplexers to route signals through the bus interconnect. An amount of signaling wiring present within a distributed multiplexed bus interconnect is optimized by eliminating individual signaling wires based upon whether an Intellectual Property core connected to the multiplexed bus interconnect transmits or receives signals from the distributed multiplexed bus interconnect.