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公开(公告)号：US11474085B2
公开(公告)日：2022-10-18
申请号：US15963809
申请日：2018-04-26
发明人： Bart Lipkens , Rui Tostoes , Kedar C. Chitale , Benjamin Ross-Johnsrud , Walter M. Presz, Jr. , Jack Saloio
IPC分类号： G01N30/76 , G01N30/46 , G01N30/72 , G01N33/543 , B01D15/38 , B01D15/18 , C07K1/22 , G01N30/02 , C12M1/42 , C12N13/00
摘要： Separation of materials is achieved using affinity binding and acoustophoretic techniques. A column provided with a fluid mixture of materials for separation and support structures may be used with acoustic waves to block flow of the support structures. The support structures can have an affinity for one or more materials in the fluid mixture. By blocking flow of the support structures, materials bound or adhered to the support structure are also blocked.
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公开(公告)号：US11214789B2
公开(公告)日：2022-01-04
申请号：US16124184
申请日：2018-09-06
发明人： Bart Lipkens , Walter M. Presz, Jr. , Brian Dutra , Jason Dionne , Goutam Ghoshal , Kedar C. Chitale
摘要： Multi-stage acoustophoretic devices for continuously separating a second fluid or a particulate from a host fluid are disclosed. Methods of operating the multi-stage acoustophoretic devices are also disclosed. The systems may include multiple acoustophoretic devices fluidly connected to one another in series, each acoustophoretic device comprising a flow chamber, an ultrasonic transducer capable of creating a multi-dimensional acoustic standing wave, and a reflector. The systems can further include pumps and flowmeters.
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公开(公告)号：US20210339169A1
公开(公告)日：2021-11-04
申请号：US17198985
申请日：2021-03-11
发明人： Bart Lipkens , Ronald Musiak , Dane Mealey , John Artis , Ali Shajii
摘要： An acoustic standing wave is utilized to separate components from a multi-component fluid, such as oil from an oil-water mixture, or cells entrained in a fluid, in a fluid flow scheme with an acoustophoresis device. For example, the flow scheme and device allows for trapping of the oil as the oil coalesces, agglomerates, and becomes more buoyant than the water. A driver and controller for the acoustophoretic device accommodate variable loading as the components are separated, thereby improving separation efficiency.
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公开(公告)号：US20210268406A1
公开(公告)日：2021-09-02
申请号：US17197932
申请日：2021-03-10
发明人： Bart Lipkens , Ronald Musiak , Dane Mealey , Ali Shajii
IPC分类号： B01D17/12 , B01D17/06 , B01D21/28 , B01D29/72 , C02F1/36 , H04R1/06 , H01L41/09 , H03H3/02 , H03H9/00 , B01D21/00 , B06B1/06 , C12M1/26 , C12M1/00 , A61M1/36
摘要： Aspects of the disclosure are directed to an apparatus for separating a second fluid or a particulate from a host fluid. That apparatus comprises a flow chamber with at least one inlet and at least one outlet. A drive circuit configured to provide a drive signal to a filter circuit configured to receive the drive signal and provide a translated drive signal. An ultrasonic transducer is cooperatively arranged with the flow chamber, and transducer includes at least one piezoelectric element configured to be driven by the current drive signal to create an acoustic standing wave in the flow chamber. At least one reflector opposing the ultrasonic transducer to reflect acoustic energy.
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公开(公告)号：US10975368B2
公开(公告)日：2021-04-13
申请号：US15672288
申请日：2017-08-08
发明人： Bart Lipkens , Brian McCarthy , Ben Ross-Johnsrud , Jason Barnes , Dane Mealey , Thomas J. Kennedy, III
摘要： An acoustophoresis device includes an acoustic chamber with a piezoelectric element located within its volume. The piezoelectric element vibrates and generates acoustic standing waves from both sides, so that particles can be separated from fluid passing through the acoustic chamber. This permits the element to be cooled more efficiently, reducing transient heat loads in the fluid traveling through the device.
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公开(公告)号：US10953436B2
公开(公告)日：2021-03-23
申请号：US15285349
申请日：2016-10-04
发明人： Bart Lipkens , Jason Dionne
IPC分类号： B06B1/06 , B01D43/00 , H01L41/047 , H01L41/09 , C12M1/00 , H01L41/053
摘要： An apparatus for separating particles from a fluid stream includes a flow chamber that has at least one inlet and at least one outlet. At least one ultrasonic transducer is located on a wall of the flow chamber. The transducer includes a piezoelectric array with at least two piezoelectric elements. The piezoelectric array includes a piezoelectric material to create a multi-dimensional acoustic standing wave in the flow chamber. A reflector is located on the wall on the opposite side of the flow chamber from the at least one ultrasonic transducer.
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公开(公告)号：US10724029B2
公开(公告)日：2020-07-28
申请号：US15647223
申请日：2017-07-11
IPC分类号： C12N13/00 , B01D21/28 , H01L41/053 , B01D17/04 , C12M1/00 , B06B1/06 , H01L41/09 , H01L41/187
摘要： A system having improved trapping force for acoustophoresis is described where the trapping force is improved by manipulation of the frequency of the ultrasonic transducer. The transducer includes a ceramic crystal. The crystal may be directly exposed to fluid flow. The crystal may be air backed, resulting in a higher Q factor.
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公开(公告)号：US10322949B2
公开(公告)日：2019-06-18
申请号：US15490878
申请日：2017-04-18
发明人： Bart Lipkens , Walter M. Presz, Jr. , Kedar Chitale , Brian McCarthy , Benjamin Ross-Johnsrud , Thomas J. Kennedy, III , Dane Mealey , Brian Dutra , David Sokolowski
IPC分类号： C02F1/36 , B06B1/06 , B01D17/04 , C02F1/40 , B01D19/00 , B01D21/28 , C12M1/42 , G10K11/28 , C12N1/02 , C12N13/00 , C12M1/00 , H01L41/09
摘要： Separation of particles or droplets from a host fluid may be achieved using a transducer and/or reflector that is a thin, non-planar structure. The thin non-planar structure improves operation of an acoustic standing wave generated by an acoustic transducer. The structure may operate as a pressure release boundary and may be constructed as plastic film.
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公开(公告)号：US10161926B2
公开(公告)日：2018-12-25
申请号：US15180015
申请日：2016-06-11
发明人： Rudolf Gilmanshin , Bart Lipkens
IPC分类号： B01D43/00 , G01N33/49 , C12Q1/24 , G01N33/574 , B01L3/00 , B06B1/06 , B01D21/28 , B03B1/04 , G01N15/14 , A61M1/36 , G01N15/10
摘要： Devices and methods for inspecting, detecting, isolating, monitoring, characterizing, or separating pathogens in blood containing blood cells are disclosed. The devices include a flow chamber having a solvent inlet, at least one host-fluid inlet, a particulate outlet, at least one residual outlet, and a reflector. The methods include trapping the pathogens in the acoustic standing wave, introducing a solvent into the flow chamber, and removing the pathogens from the device. Devices and methods for inspecting, detecting, isolating, monitoring, characterizing, or separating specialized circulating cells in blood containing blood cells are also disclosed. The devices include a flow chamber having at least one inlet and at least one outlet, and a microscope objective and a cover glass. The methods include driving the transducer to create an acoustic standing wave in the flow chamber and microbubbles in the blood.
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公开(公告)号：US09796607B2
公开(公告)日：2017-10-24
申请号：US14623906
申请日：2015-02-17
发明人： Edward A. Rietman , Bart Lipkens
CPC分类号： C02F1/441 , B01D63/06 , B01D63/065 , B01D2311/26 , B01D2313/24 , B01D2313/36 , B01D2321/2075 , C02F1/34 , C02F1/36 , C02F2201/002 , Y02A20/131
摘要： Disclosed herein are systems and methods for desalination of salt water based on an engineered acoustic field that causes constructive and destructive interference at precomputed spatial positions. The engineered acoustic field can cause high-pressure and low-pressure regions where desalination membranes are located. The induced pressure from the acoustic field can force pure water through the membranes leaving ionic and dissolved molecular species behind.
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