发明授权
- 专利标题： Formulation of stabilized cationic transfection agent(s) /nucleic acid particles
- 专利标题（中）： 稳定的阳离子转染剂/核酸颗粒的制剂
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申请号： US09369883申请日： 1999-08-09
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公开(公告)号： US06884430B1公开(公告)日： 2005-04-26
- 发明人: Joël Crouzet , Bruno Pitard
- 申请人： Joël Crouzet , Bruno Pitard
- 申请人地址： FR Antony
- 专利权人： Aventis Pharma S.A.
- 当前专利权人： Aventis Pharma S.A.
- 当前专利权人地址： FR Antony
- 代理机构： Finnegan, Henderson, Farabow, Garrett, & Dunner, L.L.P.
- 优先权： FR9701467 19970210
- 主分类号： A61K9/00
- IPC分类号： A61K9/00 ; A61K9/107 ; A61K9/127 ; A61K47/10 ; A61K47/48 ; A61K48/00
摘要：
The invention concerns a composition containing stabilized particles of cationic transfection agents/nucleic acid complexes characterized in that it includes besides said transfection agent and nucleic acid at least a non-ionic surfactant in sufficient amount for preventing the aggregation of the particles in course of time. In a preferred embodiment, the surfactant is a polyoxyalkylene or a derivative thereof.
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