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    Enzyme combinations for destroying proliferative cells
    5.
    发明授权
    Enzyme combinations for destroying proliferative cells 失效
    用于破坏增殖细胞的酶组合

    公开(公告)号：US06518062B1

    公开(公告)日：2003-02-11

    申请号：US09125576

    申请日：1998-09-10

    申请人： Francis Blanche ,  Béatrice Cameron ,  Michel Couder ,  Joël Crouzet

    发明人： Francis Blanche ,  Béatrice Cameron ,  Michel Couder ,  Joël Crouzet

    IPC分类号： C12N1500

    CPC分类号： A61K38/45 ,  A61K48/00 ,  C12N9/1211 ,  A61K2300/00

    摘要： Enzyme combinations useful for destroying cells, particularly proliferative cells, are disclosed. In particular, a combination of the following enzymes has been found to enhance the toxicity of nucleoside analogues to proliferating cells: an enzyme that phosphorylates the non-toxic nucleoside analogue to generate a monophosphate analogue, an enzyme that phosphorylates the monophosphate analogue to generate a diphosphate analogue and an enzyme that phosphorylates the diphosphate analogue to generate a toxic triphosphate analogue. Vectors enabling the intracellular expression and transfer of the enzyme combinations, as well as their therapeutic use, particularly in anti-cancer gene therapy, are also disclosed.

    摘要翻译： 公开了可用于破坏细胞，特别是增殖细胞的酶组合。 特别地，已经发现以下酶的组合增强核苷类似物对增殖细胞的毒性：使无毒核苷类似物磷酸化以产生单磷酸酯类似物的酶，磷酸化单磷酸酯类似物以产生二磷酸 类似物和使磷酸化类似物产生有毒的三磷酸酯类似物的酶。 还公开了能够进行酶组合的细胞内表达和转移的载体及其治疗用途，特别是在抗癌基因治疗中。

    METHOD FOR THE PROGNOSIS OF PROGRESSION OF THE HIV DISEASE
    8.
    发明申请
    METHOD FOR THE PROGNOSIS OF PROGRESSION OF THE HIV DISEASE 审中-公开
    预防艾滋病毒进展的方法

    公开(公告)号：US20140024018A1

    公开(公告)日：2014-01-23

    申请号：US14000880

    申请日：2012-02-21

    申请人： Laurence Meyer ,  Vincent Viellard ,  Patrice Debre ,  Joël Crouzet

    发明人： Laurence Meyer ,  Vincent Viellard ,  Patrice Debre ,  Joël Crouzet

    IPC分类号： C12Q1/70

    CPC分类号： C12Q1/703 ,  G01N33/56988

    摘要： An in vitro method for the prognosis of progression of an HIV-1 infection in a patient infected with an HIV-1 virus, comprising the steps of: a) measuring the level of antibodies directed against the 3S peptide of SEQ ID NO 2 in a sample collected from the said patient, b) comparing the level of anti-3S antibodies measured at step a) with a reference value of anti-3S antibody level that is indicative of the progression of the HIV-1 infection.

    摘要翻译： 用于预测感染HIV-1病毒的患者中HIV-1感染进展的体外方法，包括以下步骤：a）测量针对SEQ ID NO 2的3S肽的抗体水平 从所述患者收集的样品，b）将步骤a）中测量的抗-33抗体的水平与指示HIV-1感染进展的抗-33抗体水平的参考值进行比较。